The relationship among acute-phase responce proteins, cytokines, and hormones in various gastrointestinal cancer types patients with cachectic

• Published in: Human & experimental toxicology Vol. 31; no. 2; pp. 117 - 125
• Main Authors: Kemik, O, Kemik, AS, Begenik, H, Erdur, FM, Emre, H, Sumer, A, Purisa, S, Tuzun, S, Kotan, C
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.02.2012; Sage Publications; Sage Publications Ltd
• Subjects: Adiponectin; Adult; Aged; Albumin; Biological and medical sciences; biomarkers; C-reactive protein; C-Reactive Protein - analysis; Cachexia; Cachexia - blood; Cachexia - etiology; Cancer; Colon; Colon cancer; Cytokines; Cytokines - blood; Esophagus; Female; Gastroenterology. Liver. Pancreas. Abdomen; Gastrointestinal diseases; Gastrointestinal Neoplasms - blood; Gastrointestinal Neoplasms - complications; ghrelin; Hormones; Humans; Interleukin 1; Interleukin 10; Interleukin 6; Interleukin 8; Leptin; Male; Malignancy; Medical sciences; Middle Aged; midkine; Pancreas; Peptide Hormones - blood; Proteins; Rectum; Serum Albumin - analysis; Serum levels; Statistical analysis; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Toxicology; Tumor necrosis factor- alpha; Tumors; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - blood; Vascular Endothelial Growth Factor C - blood; Vascular Endothelial Growth Factor Receptor-1 - blood; cytokines; acute-phase response protein; gastrointestinal cancer types; hormones; cachexia; Human; Hormone; Gastrointestinal cancer; Cytokine; Cachexia; Malignant tumor; Acute phase protein; Digestive diseases; Intestinal disease; Cancer; Gastric disease
• ISSN: 0960-3271; 1477-0903
• DOI: 10.1177/0960327111417271

Background: Acute-phase response proteins (APRPs), cytokines, and hormones have been claimed to be an independent, important factor of cancers. We suggest that in gastrointestinal system cancers, changes in APRP, cytokines, and hormones are associated.Methods: C-reactive protein (CRP), albumin, interleukin 1α (IL-1α), IL-1β, IL-6, IL-8, IL-10, tumor necrosis factor α (TNF-α), midkine, vascular endothelial growth factor-A(VEGF-A), VEGF-C, VEGF receptor 1 (VEGFR1), leptin, adiponectin, and ghrelin serum levels are studied in 148 gastrointestinal system cancer types and 40 healthy controls.Results: We found statistically significant differences and correlations between groups. We found significantly higher serum CRP, IL-1α, IL-1β, IL-6, IL-8, IL-10, TNF-α, VEGF-A, VEGF-C, VEGFR1, and leptin concentrations in patients with esophageal, gastric, pancreas, colon, and rectum cancers than controls (p < 0.001, p < 0.0001). But, we found lower levels of the serum albumin, midkine, adiponectin, and ghrelin in patients with esophageal, gastric, pancreas, colon, and rectum cancers compared to control subjects (p < 0.05, p < 0.001).Conclusions: Cachexia in gastrointestinal system cancer types is associated with changes in APRP, cytokines, and hormone concentrations. This may be reflected between the outcomes in malignancies and the biomarkers.