Gut microbiota dysbiosis in polycystic ovary syndrome: Mechanisms of progression and clinical applications

Polycystic ovary syndrome (PCOS) is the most common endocrine diseases in women of childbearing age that leads to menstrual disorders and infertility. The pathogenesis of PCOS is complex and has not yet been fully clarified. Gut microbiota is associated with disorders of lipid, glucose, and steroid...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in cellular and infection microbiology Vol. 13; p. 1142041
Main Authors Sun, Yan, Gao, Shouyang, Ye, Cong, Zhao, Weiliang
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 24.02.2023
Subjects
Cellular and Infection Microbiology
Dysbiosis - complications
Female
Gastrointestinal Microbiome - physiology
gut microbiota
Humans
infertility
Insulin
Insulin Resistance
Polycystic ovary syndrome
Polycystic Ovary Syndrome - drug therapy
women
Polycystic ovary syndrome
insulin
infertility
gut microbiota
women
Online AccessGet full text

Cover

More Information
Summary:Polycystic ovary syndrome (PCOS) is the most common endocrine diseases in women of childbearing age that leads to menstrual disorders and infertility. The pathogenesis of PCOS is complex and has not yet been fully clarified. Gut microbiota is associated with disorders of lipid, glucose, and steroid hormone metabolish. A large body of studies demonstrated that gut microbiota could regulate the synthesis and secretion of insulin, and affect androgen metabolism and follicle development, providing us a novel idea for unravelling the pathogenesis of PCOS. The relationship between gut microbiota and the pathogenesis of PCOS is particularly important. This study reviewed recent research advances in the roles of gut microbiota in the occurrence and development of PCOS. It is expected to provide a new direction for the treatment of PCOS based on gut microbiota.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
This article was submitted to Clinical Microbiology, a section of the journal Frontiers in Cellular and Infection Microbiology
Reviewed by: Yongbin Shen, Harbin Medical University, China; Ershun Zhou, Foshan University, China; Jie Chen, Sichuan University, China
Edited by: Bo Liu, Inner Mongolia Agricultural University, China
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2023.1142041