Antibiotic Therapy for 6 or 12 Weeks for Prosthetic Joint Infection

• Published in: The New England journal of medicine Vol. 384; no. 21; pp. 1991 - 2001
• Main Authors: Bernard, Louis, Arvieux, Cédric, Brunschweiler, Benoit, Touchais, Sophie, Ansart, Séverine, Bru, Jean-Pierre, Oziol, Eric, Boeri, Cyril, Gras, Guillaume, Druon, Jérôme, Rosset, Philippe, Senneville, Eric, Bentayeb, Houcine, Bouhour, Damien, Le Moal, Gwenaël, Michon, Jocelyn, Aumaître, Hugues, Forestier, Emmanuel, Laffosse, Jean-Michel, Begué, Thierry, Chirouze, Catherine, Dauchy, Fréderic-Antoine, Devaud, Edouard, Martha, Benoît, Burgot, Denis, Boutoille, David, Stindel, Eric, Dinh, Aurélien, Bemer, Pascale, Giraudeau, Bruno, Issartel, Bertrand, Caille, Agnès
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 27.05.2021
• Subjects: Adverse events; Aged; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - adverse effects; Antibiotics; Bacteria; Combined Modality Therapy; Drug Administration Schedule; Female; Fistula; Hip Prosthesis - adverse effects; Hospitals; Humans; Infections; Infectious diseases; Intention to Treat Analysis; Joint diseases; Knee Prosthesis - adverse effects; Life Sciences; Male; Medication Adherence - statistics & numerical data; Middle Aged; Pathogens; Patients; Persistent infection; Prostheses; Prosthesis-Related Infections - drug therapy; Prosthesis-Related Infections - surgery; Retention; Santé publique et épidémiologie; Sensitivity analysis; Surgery; Treatment Failure
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJMoa2020198

The appropriate duration of antimicrobial therapy for bacterial prosthetic joint infection is debated. In this open-label, randomized, controlled, noninferiority trial involving 410 patients with prosthetic joint infection at 28 centers across France, antimicrobial therapy for 6 weeks was compared with therapy for 12 weeks and was not found to be noninferior.