Long-term outcome and survival of surgically treated supratentorial low-grade glioma in adult patients

• Published in: Acta neurochirurgica Vol. 151; no. 11; pp. 1359 - 1365
• Main Authors: Rezvan, Ahmadi, Christine, Dictus, Christian, Hartmann, Olga, Zürn, Lutz, Edler, Marius, Hartmann, Stephanie, Combs, Christel, Herold-Mende, Rainer, Wirtz Christian, Andreas, Unterberg
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.11.2009; Springer Nature B.V
• Subjects: Adolescent; Adult; Age Factors; Aged; Brain Neoplasms - mortality; Brain Neoplasms - pathology; Brain Neoplasms - surgery; Clinical Article; Combined Modality Therapy - methods; Combined Modality Therapy - statistics & numerical data; Drug Therapy - methods; Drug Therapy - statistics & numerical data; Female; Glioma - mortality; Glioma - pathology; Glioma - surgery; Humans; Interventional Radiology; Magnetic Resonance Imaging; Male; Medicine; Medicine & Public Health; Middle Aged; Minimally Invasive Surgery; Monitoring, Intraoperative; Neoplasm Invasiveness - physiopathology; Neoplasm Invasiveness - prevention & control; Neoplasm Recurrence, Local - epidemiology; Neoplasm Recurrence, Local - prevention & control; Neoplasm Recurrence, Local - surgery; Neurology; Neuronavigation; Neuroradiology; Neurosurgery; Neurosurgical Procedures - methods; Neurosurgical Procedures - statistics & numerical data; Preoperative Care; Prognosis; Radiotherapy - methods; Radiotherapy - statistics & numerical data; Retrospective Studies; Stereotaxic Techniques; Surgical Orthopedics; Survival Rate; Treatment Outcome; Young Adult; Extent of surgery; Survival; Low-grade glioma
• ISSN: 0001-6268; 0942-0940
• DOI: 10.1007/s00701-009-0435-x

Purpose The appropriate management of low-grade gliomas is still a matter of debate. So far, there are no randomized studies that analyze the impact of surgical resection on patient outcome. The value of the data obtained from the few retrospective reports available is often limited. Patients and methods In the present study, we performed an analysis on data of 130 adult low-grade glioma patients. Extent of the resection was evaluated in correlation to the overall survival (OS) and progression-free survival (PFS) using Cox regression multivariate analysis. Results Extended surgery was shown to prolong OS and PFS significantly. Re-surgery in the case of a tumor relapse has a significant impact on OS and PFS, too. Conclusions In summary, we could retrospectively evaluate a large case series of well-defined low-grade gliomas patients with a long follow-up period showing that extended surgery would be the most effective therapy for low-grade glioma patients even in recurrent diseases.