Gold nanoplatform for near-infrared light-activated radio-photothermal gas therapy in breast cancer

Although radiotherapy is one of the most common treatments for triple-negative breast cancer (TNBC), it frequently has unsatisfactory therapeutic outcomes due to the radiation resistance of tumor tissues. Therefore, a synergistic strategy is urgently needed to increase therapeutic responses and prol...

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Published inFrontiers in bioengineering and biotechnology Vol. 10; p. 1098986
Main Authors Zuo, Shuting, Wang, Zhenyu, Zhao, Liping, Wang, Jing
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 06.01.2023
Subjects
Bioengineering and Biotechnology
breast cancer
combination therapies
gas therapy
nitric oxide
radio-sensitization
gas therapy
breast cancer
nitric oxide
radio-sensitization
combination therapies
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Summary:Although radiotherapy is one of the most common treatments for triple-negative breast cancer (TNBC), it frequently has unsatisfactory therapeutic outcomes due to the radiation resistance of tumor tissues. Therefore, a synergistic strategy is urgently needed to increase therapeutic responses and prolong patient survival. Herein, we constructed gold nanocages (GNCs) loaded with a hyperpyrexia-sensitive nitric oxide (NO) donor (thiolate cupferron) to integrate extrinsic radiosensitization, local photothermal therapy, and near-infrared-activated NO gas therapy. The resulting nanoplatform (GNCs@NO) showed a high photothermal conversion efficiency, which induced the death of cancer cells and facilitated rapid NO release in tumor tissues. The radiosensitizing efficacy of GNCs@NO was further demonstrated and . Importantly, the released NO reacted with the reactive oxide species induced by radiotherapy to produce more toxic reactive nitrogen species, exerting a synergistic effect to improve anticancer efficacy. Thus, GNCs@NO demonstrated excellent effects as a combination therapy with few adverse effects. Our work proposes a promising nanoplatform for the radio/photothermal/gas treatment of TNBC.
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This article was submitted to Biomaterials, a section of the journal Frontiers in Bioengineering and Biotechnology
Reviewed by: Yuewu Zhao, Suzhou Institute of Nano-tech and Nano-bionics (CAS), China
Edited by: Hasan Uludag, University of Alberta, Canada
Zhimin Chang, Suzhou Institute of Biomedical Engineering and Technology (CAS), China
Tao Yang, Soochow University, China
ISSN:2296-4185
2296-4185
DOI:10.3389/fbioe.2022.1098986