Synergistic effect between prelimbic 5-HT3 and CB1 receptors on memory consolidation deficit in adult male Sprague–Dawley rats: An isobologram analysis

• Published in: Neuroscience Vol. 317; pp. 173 - 183
• Main Authors: Ahmadi-Mahmoodabadi, N, Nasehi, M, Emam Ghoreishi, M, Zarrindast, M.-R
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 11.03.2016
• Subjects: ACPA; Animals; Arachidonic Acids - toxicity; Avoidance Learning - drug effects; Biguanides - toxicity; Bridged Bicyclo Compounds, Heterocyclic - therapeutic use; Cannabinoid Receptor Agonists - toxicity; Cerebral Cortex - drug effects; Cerebral Cortex - physiology; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; inhibitory avoidance (IA) memory; m-CPBG; Male; Memory Disorders - chemically induced; Memory Disorders - drug therapy; Memory Disorders - metabolism; Motor Activity - drug effects; Neurology; Oxazines - therapeutic use; pre-limbic area; Rats; Rats, Sprague-Dawley; Reaction Time - drug effects; Receptor, Cannabinoid, CB1 - metabolism; Receptors, Serotonin, 5-HT3 - metabolism; Serotonin Antagonists - toxicity; Serotonin Receptor Agonists - toxicity; Y-25130; intraperitoneal; inhibitory avoidance; IP; m-CPBG; inhibitory avoidance (IA) memory; medial pre-frontal cortex; cannabinoid receptor; ACPA; CB R; mPFC; m-Chlorophenylbiguanide hydrochloride; Arachidonylcyclopropylamide; IA; Y-25130; pre-limbic area; PL; prelimbic
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2015.12.010

Highlights • Intra-PL injection of ACPA and m-CPBG but not Y-25130 impaired memory consolidation. • m-CPBG potentiated, while Y-25130 restored ACPA-induced memory consolidation deficit. • Synergistic effect between ACPA and m-CPBG on memory consolidation deficit.