Changes in synaptic plasticity and expression of glutamate receptor subunits in the CA1 and CA3 areas of the hippocampus after transient global ischemia

• Published in: Neuroscience Vol. 327; pp. 64 - 78
• Main Authors: Han, Xin-Jia, Shi, Zhong-Shan, Xia, Luo-Xing, Zhu, Li-Hui, Zeng, Ling, Nie, Jun-Hua, Xu, ZaoCheng, Ruan, Yi-Wen
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 07.07.2016
• Subjects: Animals; CA1 Region, Hippocampal - metabolism; CA3 Region, Hippocampal - metabolism; Cell Death - physiology; glutamate receptor; Glutamic Acid - metabolism; hippocampus; Ischemic Attack, Transient - metabolism; Male; Neurology; Neuronal Plasticity - physiology; protein expression; Rats, Wistar; Receptors, AMPA - metabolism; Receptors, Glutamate - metabolism; Receptors, N-Methyl-D-Aspartate - metabolism; synapse; Synapses - metabolism; transient global ischemia; ultrastructure; AMPA; N-methyl- d-aspartate; TAS; pyramidal layer; CAMKII; transient global ischemia; brain-derived neurotrophic factor; ID; protein expression; common carotid arteries; cAMP response element binding protein; N-methyl- d-aspartate receptors; PSD; DSR; AAD; calcium/calmodulin-dependent protein kinase II; NMDARs; synapse; ultrastructure; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors; fluorescence intensity; postsynaptic density-95; PSR; ischemic depolarization; direct current; AAS; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; TSS; asymmetric axodendritic synapses; SAD; distal stratum radiatum; distal stratum radium; FD; SAS; proximal stratum radiatum; stratum pyramidal cell layer; total symmetric axospinous synapses; total asymmetric synapses; CREB; NMDA; SO; SP; asymmetric axospinous synapses; CCA; postsynaptic density; hippocampus; BDNF; symmetric axospinous synapses; AMPARs; PSD95; stratum oriens; glutamate receptor; PL; DC; symmetric axodendritic synapses
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2016.04.011

Highlights • Transient global ischemia induced changes in number of synapses and thickness of PSD in the CA1 area but not CA3 region. • The NR2B/NR2A and GluR1/GluR2 ratios increased in the CA1 area but not CA3 region after ischemia. • Changes in synaptic morphology and glutamate receptor subunits in the CA1 area may be related to ischemic-neuronal death.