Perioperative blood transfusions and decreased long-term survival in esophageal cancer

• Published in: Journal of thoracic and cardiovascular surgery Vol. 112; no. 2; pp. 341 - 348
• Main Authors: Swisher, Stephen G., Holmes, E.Carmack, Hunt, Kelly K., Gornbein, Jeffrey A., Zinner, Michael J., McFadden, David W.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Philadelphia, PA Mosby, Inc 01.08.1996; AATS/WTSA; Elsevier
• Subjects: Adenocarcinoma - surgery; Bacterial Infections; Biological and medical sciences; Blood Transfusion - statistics & numerical data; Blood Volume; Carcinoma, Squamous Cell - surgery; Erythrocyte Transfusion; Esophageal Neoplasms - surgery; Esophagus; Female; Humans; Immunosuppression - adverse effects; Isotonic Solutions; Linear Models; Los Angeles - epidemiology; Male; Medical sciences; Multivariate Analysis; Neoplasm Recurrence, Local; Plasma; Plasma Substitutes - therapeutic use; Platelet Transfusion; Postoperative Complications; Proportional Hazards Models; Retrospective Studies; Risk Factors; Serum Albumin - therapeutic use; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Survival Rate; Transfusion Reaction; Human; Carcinoma; Prognosis; Transfusion; Esophageal disease; Esophagectomy; Intraoperative; Malignant tumor; Survival; Blood; Esophagus; Treatment; Follow up study; Surgery; Digestive diseases
• ISSN: 0022-5223; 1097-685X
• DOI: 10.1016/S0022-5223(96)70260-X

We evaluated retrospectively the effect of perioperative blood transfusions on survival in esophageal cancer. The records of all patients who underwent esophageal resection ( n = 316) at UCLA Medical Center from 1970 to 1993 were reviewed. Statistical analysis included univariate (log-rank χ 2) and multivariate (Cox proportional hazards) analyses with other known risk factors. High-volume blood transfusions (>8 units) but not low-volume blood transfusions (1 to 8 units) were associated with a significant decrease in long-term survival (median survival: no transfusion, 22 months; low-volume blood transfusion, 14.5 months, versus high-volume blood transfusions, 6.5 months; p < 0.01). Multivariate analysis revealed that the shorter survival with high-volume blood transfusions was a result of an increased number of postoperative complications. High-volume blood transfusions were not associated with increases in tumor recurrence or infectious complications. The association between shorter survival and high-volume blood transfusions in esophageal cancer may, therefore, be because of the circumstances necessitating transfusion rather than any immunosuppressive effects of the transfused blood. These findings suggest that the transfusion of blood does not by itself decrease the chance of cure after esophageal resection. (J T horac C ardiovasc S urg 1996;112:341-8)