The Mechanobiology of Vascular Remodeling in the Aging Lung
Aging is accompanied by declining lung function and increasing susceptibility to lung diseases. The role of endothelial dysfunction and vascular remodeling in these changes is supported by growing evidence, but underlying mechanisms remain elusive. In this review we summarize functional, structural,...
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Published in | Physiology (Bethesda, Md.) Vol. 37; no. 1; pp. 28 - 38 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Physiological Society
01.01.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Aging is accompanied by declining lung function and increasing susceptibility to lung diseases. The role of endothelial dysfunction and vascular remodeling in these changes is supported by growing evidence, but underlying mechanisms remain elusive. In this review we summarize functional, structural, and molecular changes in the aging pulmonary vasculature and explore how interacting aging and mechanobiological cues may drive progressive vascular remodeling in the lungs. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-2 P. B. Dieffenbach and A. Aravamudhan contributed equally to this work. L. E. Fredenburgh and D. J. Tschumperlin contributed equally to this work. |
ISSN: | 1548-9213 1548-9221 |
DOI: | 10.1152/physiol.00019.2021 |