The Mechanobiology of Vascular Remodeling in the Aging Lung

Aging is accompanied by declining lung function and increasing susceptibility to lung diseases. The role of endothelial dysfunction and vascular remodeling in these changes is supported by growing evidence, but underlying mechanisms remain elusive. In this review we summarize functional, structural,...

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Published inPhysiology (Bethesda, Md.) Vol. 37; no. 1; pp. 28 - 38
Main Authors Dieffenbach, Paul B, Aravamudhan, Aja, Fredenburgh, Laura E, Tschumperlin, Daniel J
Format Journal Article
LanguageEnglish
Published United States American Physiological Society 01.01.2022
Subjects
Aging
Biophysics
Humans
Lung
Review
Vascular Diseases
Vascular Remodeling
senescence
pulmonary
matrix
stiffness
vessel
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Summary:Aging is accompanied by declining lung function and increasing susceptibility to lung diseases. The role of endothelial dysfunction and vascular remodeling in these changes is supported by growing evidence, but underlying mechanisms remain elusive. In this review we summarize functional, structural, and molecular changes in the aging pulmonary vasculature and explore how interacting aging and mechanobiological cues may drive progressive vascular remodeling in the lungs.
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P. B. Dieffenbach and A. Aravamudhan contributed equally to this work. L. E. Fredenburgh and D. J. Tschumperlin contributed equally to this work.
ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.00019.2021