Estradiol and angiotensin II crosstalk in hydromineral balance: Role of the ERK1/2 and JNK signaling pathways

• Published in: Neuroscience Vol. 322; pp. 525 - 538
• Main Authors: Almeida-Pereira, G, Coletti, R, Mecawi, A.S, Reis, L.C, Elias, L.L.K, Antunes-Rodrigues, J
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 13.05.2016
• Subjects: Angiotensin II - administration & dosage; Angiotensin II - metabolism; Animals; Central Nervous System Agents - administration & dosage; Central Nervous System Agents - metabolism; Drinking - drug effects; Drinking - physiology; Estradiol - administration & dosage; Estradiol - metabolism; Female; JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors; JNK Mitogen-Activated Protein Kinases - metabolism; MAP Kinase Signaling System - drug effects; MAP Kinase Signaling System - physiology; Neurology; ovariectomized rats; Ovariectomy; Oxytocin - secretion; Paraventricular Hypothalamic Nucleus - drug effects; Paraventricular Hypothalamic Nucleus - metabolism; Random Allocation; Rats, Wistar; sodium intake; Sodium, Dietary; Supraoptic Nucleus - drug effects; Supraoptic Nucleus - metabolism; vasopressin secretion; Vasopressins - secretion; water intake; ovariectomized rats; DMSO; JNK; PVN; OVLT; phosphate-buffered saline; E2; G-protein-coupled receptors; icv; PBS; c-Jun N-terminal kinase; oxytocin; MnPO; vasopressin; MAPK phosphatase 1; PKC; MAPK; ER; ERK1/2; angiotensin II; supraoptic nucleus; AVP; paraventricular nucleus; extracellular-signal-regulated kinase; mitogen-activated protein kinase family; sodium intake; subfornical organ; ovariectomized; OVX; dimethyl sulfoxide; water intake; GPCRs; vasopressin secretion; intracerebroventricular; SFO; AT1; protein kinase C; estradiol; median preoptic nuclei; ANGII; DUSPs; estrogen receptor; OT; oxytocin secretion; organum vasculosum of the lamina terminalis; SON; dual-specificity phosphatases; MKP-1; ANGII type 1 receptor
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2016.02.067

Highlights • The effect of estradiol on ANGII-induced fluid intake requires the ERK1/2 and JNK signaling. • JNK signaling is involved in fluid intake induced by ANGII in OVX rats. • Estradiol therapy decreased ANGII-induced oxytocin and vasopressin secretion. • The vasopressin secretion induced by ANGII requires ERK1/2 signaling in OVX rats.