Chemo-free maintenance therapy in adult T-cell acute lymphoblastic leukemia: A case report and literature review

• Published in: Frontiers in pharmacology Vol. 14; p. 1051305
• Main Authors: Song, Yuanbin, Chen, Shuzhao, Liu, Chenfei, Chen, Lezong, Wang, Weida, Wu, Bingyi, Liang, Yang
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 17.02.2023
• Subjects: anti-programmed cell death protein 1; case report; chemo-free maintenance therapy; histone deacetylase inhibitor; literature review; Pharmacology; T-cell acute lymphoblastic leukemia; case report; anti-programmed cell death protein 1; chemo-free maintenance therapy; literature review; histone deacetylase inhibitor; T-cell acute lymphoblastic leukemia
• ISSN: 1663-9812; 1663-9812
• DOI: 10.3389/fphar.2023.1051305

Maintenance therapy in adult T-cell acute lymphoblastic leukemia (T-ALL) is the longest phase but with limited option. The classic drugs used in the maintenance phase such as 6-mercaptopurine, methotrexate, corticosteroid and vincristine have potentially serious toxicities. Optimizing therapy in the modern age, chemo-free maintenance therapy regimens for patients with T-ALL may dramatically improve the maintenance therapeutic landscape. We report here the combination of Anti-programmed cell death protein 1 antibody and histone deacetylase inhibitor as chemo-free maintenance treatment in a T-ALL patient with literature review, thus providing a unique perspective in addition to valuable information which may inform novel therapeutic approaches.