Thioglycine and l-thiovaline: Biologically active H2S-donors

• Published in: Bioorganic & medicinal chemistry Vol. 20; no. 8; pp. 2675 - 2678
• Main Authors: Zhou, Zongmin, von Wantoch Rekowski, Margarete, Coletta, Ciro, Szabo, Csaba, Bucci, Mariarosaria, Cirino, Giuseppe, Topouzis, Stavros, Papapetropoulos, Andreas, Giannis, Athanassios
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 15.04.2012; Elsevier
• Subjects: Acids; Amino Acids; Amino Acids - chemistry; Amino Acids - metabolism; Amino Acids - pharmacology; analogs & derivatives; Animal models; Animals; Aorta; Aorta - drug effects; Aorta - metabolism; Bicarbonate; bicarbonates; Biological and medical sciences; biosynthesis; cardioprotective effect; Cardiovascular diseases; chemistry; Cyclic GMP; Cyclic GMP - biosynthesis; Cyclic GMP - metabolism; cytology; drug effects; Gasotransmitters; General pharmacology; Glycine; Glycine - analogs & derivatives; Glycine - pharmacology; Hydrogen Sulfide; Hydrogen Sulfide - chemistry; Hydrogen Sulfide - metabolism; Hydrogen sulfidel; Hypertension; Medical sciences; metabolism; Mice; Miscellaneous; Myocytes, Smooth Muscle; Myocytes, Smooth Muscle - cytology; Myocytes, Smooth Muscle - drug effects; Myocytes, Smooth Muscle - metabolism; Oxidative stress; pharmacology; Pharmacology. Drug treatments; Rats; Thioglycin; Thiovalin; Valine; Valine - analogs & derivatives; Valine - pharmacology; Vasodilation; Hydrogen sulfidel; Thioglycin; Gasotransmitters; Thiovalin; Drug; Hydrogen Sulfides; Treatment; Chemical synthesis; Gasotransmitter; Research and development
• ISSN: 0968-0896; 1464-3391; 1464-3391
• DOI: 10.1016/j.bmc.2012.02.028

Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H2S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H2S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H2S donors hold promise as novel treatments for cardiovascular diseases.