PP2A as a master regulator of the cell cycle

Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell cycle, regulating almost all major pathways and cell cycle checkpoints. PP2A is involved in such diverse processes by the for...

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Bibliographic Details
Published inCritical reviews in biochemistry and molecular biology Vol. 51; no. 3; pp. 162 - 184
Main Authors Wlodarchak, Nathan, Xing, Yongna
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 03.05.2016
Subjects
Animals
Cancer
Cell Cycle
cell division
DNA Replication
Humans
MAP Kinase Signaling System
mitosis
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
phosphatase
PP2A
Protein Interaction Maps
Protein Phosphatase 2 - metabolism
Signal Transduction
TOR Serine-Threonine Kinases - metabolism
Wnt Signaling Pathway
cell division
PP2A
phosphatase
mitosis
cell cycle
Cancer
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Summary:Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell cycle, regulating almost all major pathways and cell cycle checkpoints. PP2A is involved in such diverse processes by the formation of structurally distinct families of holoenzymes, which are regulated spatially and temporally by specific regulators. Here, we review the involvement of PP2A in the regulation of three cell signaling pathways: wnt, mTOR and MAP kinase, as well as the G1→S transition, DNA synthesis and mitotic initiation. These processes are all crucial for proper cell survival and proliferation and are often deregulated in cancer and other diseases.
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ISSN:1040-9238
1549-7798
1549-7798
DOI:10.3109/10409238.2016.1143913