Phyto-factories of anti-cancer compounds: a tissue culture perspective

• Published in: Beni-Suef University Journal of Basic and Applied Sciences Vol. 11; no. 1; pp. 1 - 21
• Main Authors: Patel, Poonam, Patel, Vaibhav, Modi, Arpan, Kumar, Sushil, Shukla, Yogesh M.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 26.03.2022; Springer; SpringerOpen
• Subjects: Anticancer compounds; Bioreactors; Cancer; Chemotherapy; Forecasts and trends; Mass cultivation; Medicine; Medicine & Public Health; Medicine, Botanic; Medicine, Herbal; Plant metabolites; Plant tissue culture; Review; Saponins; Vincristine; Canada; India; Plant tissue culture; Anticancer compounds; Bioreactors; Mass cultivation
• ISSN: 2314-8543; 2314-8535; 2314-8543
• DOI: 10.1186/s43088-022-00203-5

Background Cancer is one of the most critical but ubiquitous causes of death grappled from past decades. Widely used chemotherapy with cytotoxic activity blocks/ kills the cancer cell. The compounds targeted for anticancerous activity are either derived synthetically or naturally (through plants or microbial origin). Current day, versatile role of plants in medicinal field has been attributed to the secondary metabolites it produces, known for their anticancer activity. Therefore, discovery, identification and commercial production of such novel anticancer drugs is escalated and are centerpiece for pharmaceuticals. Main body A biotechnological approach, principally tissue culture, leads the candidacy to be an alternative method for production of anticancer compounds. A wide range of bioactive agents like alkaloids, steroids, phenolics, saponins, flavonoids, and terpenoids are in huge demand commercially. Plant tissue culture applications are constructively more advantageous over conventional methods in terms of their continuous, controlled, aseptic production, large scale and de novo synthesis opportunity. Various bioreactors are used for mass cultivation of bioactive compound at commercial level. For example: stirred tank reactors are used for production of shikonin from Lithospermum erythrorhizon, vincristine from Catharanthus roseus , podophyllotoxin from Podophyllum etc . Strategies like callus culture, suspension culture and hairy root culture are opted for mass cultivation of these bioactives. Conclusions This review summarizes plant tissue culture as a promising strategy proven to be a colossal breakthrough in reliable and continuous production of existing and novel anticancer compounds and help in combating the increasing future demands.