Viable Tumor Tissue Adherent to Needle Applicators after Local Ablation: A Risk Factor for Local Tumor Progression

• Published in: Annals of surgical oncology Vol. 18; no. 13; pp. 3702 - 3710
• Main Authors: Snoeren, Nikol, Huiskens, Joost, Rijken, Arjen M., van Hillegersberg, Richard, van Erkel, Arian R., Slooter, Gerrit D., Klaase, Joost M., van den Tol, Petrousjka M., Ten Kate, Fibo J. W., Jansen, Maarten C., van Gulik, Thomas M.
• Format: Journal Article
• Language: English
• Published: New York Springer-Verlag 01.12.2011; Springer Nature B.V
• Subjects: Aged; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - secondary; Carcinoma, Hepatocellular - surgery; Catheter Ablation; Disease Progression; Female; Follow-Up Studies; Gastrointestinal Oncology; Humans; Liver Neoplasms - mortality; Liver Neoplasms - pathology; Liver Neoplasms - surgery; Male; Medicine; Medicine & Public Health; Needles - adverse effects; Neoplasm Recurrence, Local - etiology; Neoplasm Recurrence, Local - mortality; Neoplasm Recurrence, Local - pathology; Oncology; Prognosis; Prospective Studies; Risk Factors; Surgery; Surgical Oncology; Survival Rate; Tomography, X-Ray Computed; Nicotinamide Adenine Dinucleotide Phosphate; Pringle Maneuver; Local Tumor Progression; Viable Tumor Cell
• ISSN: 1068-9265; 1534-4681
• DOI: 10.1245/s10434-011-1762-8

Background Local tumor progression (LTP) is a serious complication after local ablation of malignant liver tumors, negatively influencing patient survival. LTP may be the result of incomplete ablation of the treated tumor. In this study, we determined whether viable tumor cells attached to the needle applicator after ablation was associated with LTP and disease-free survival. Methods In this prospective study, tissue was collected of 96 consecutive patients who underwent local liver ablations for 130 liver malignancies. Cells and tissue attached to the needle applicators were analyzed for viability using glucose-6-phosphate-dehydrogenase staining and autofluorescence intensity levels of H&E stained sections. Patients were followed-up until disease progression. Results Viable tumor cells were found on the needle applicators after local ablation in 26.7% of patients. The type of needle applicator used, an open approach, and the omission of track ablation were significantly correlated with viable tumor tissue adherent to the needle applicator. The presence of viable cells was an independent predictor of LTP. The attachment of viable cells to the needle applicators was associated with a shorter time to LTP. Conclusions Viable tumor cells adherent to the needle applicators were found after ablation of 26.7% of patients. An independent risk factor for viable cells adherent to the needle applicators is the omission of track ablation. We recommend using only RFA devices that have track ablation functionality. Adherence of viable tumor cells to the needle applicator after local ablation was an independent risk factor for LTP.