Spiral drawing analysis with a smart ink pen to identify Parkinson's disease fine motor deficits

• Published in: Frontiers in neurology Vol. 14; p. 1093690
• Main Authors: Toffoli, Simone, Lunardini, Francesca, Parati, Monica, Gallotta, Matteo, De Maria, Beatrice, Longoni, Luca, Dell'Anna, Maria Elisabetta, Ferrante, Simona
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 10.02.2023
• Subjects: eHealth; movement disorders; Neurology; Parkinson's disease; smart ink pen; spiral analysis; spiral analysis; smart ink pen; Parkinson's disease; movement disorders; eHealth
• ISSN: 1664-2295; 1664-2295
• DOI: 10.3389/fneur.2023.1093690

Since the uptake of digitizers, quantitative spiral drawing assessment allowed gaining insight into motor impairments related to Parkinson's disease. However, the reduced naturalness of the gesture and the poor user-friendliness of the data acquisition hamper the adoption of such technologies in the clinical practice. To overcome such limitations, we present a novel smart ink pen for spiral drawing assessment, intending to better characterize Parkinson's disease motor symptoms. The device, used on paper as a normal pen, is enriched with motion and force sensors. Forty-five indicators were computed from spirals acquired from 29 Parkinsonian patients and 29 age-matched controls. We investigated between-group differences and correlations with clinical scores. We applied machine learning classification models to test the indicators ability to discriminate between groups, with a focus on model interpretability. Compared to control, patients' drawings were characterized by reduced fluency and lower but more variable applied force, while tremor occurrence was reflected in kinematic spectral peaks selectively concentrated in the 4-7 Hz band. The indicators revealed aspects of the disease not captured by simple trace inspection, nor by the clinical scales, which, indeed, correlate moderately. The classification achieved 94.38% accuracy, with indicators related to fluency and power distribution emerging as the most important. Indicators were able to significantly identify Parkinson's disease motor symptoms. Our findings support the introduction of the smart ink pen as a time-efficient tool to juxtapose the clinical assessment with quantitative information, without changing the way the classical examination is performed.