Regulatory mechanism of circular RNA involvement in osteoarthritis

Osteoarthritis (OA) causes joint pain, stiffness, and dysfunction in middle-aged and older adults; however, its pathogenesis remains unclear. Circular RNAs (circRNAs) are differentially expressed in patients with OA and participate in a multigene, multitarget regulatory network. CircRNAs are involve...

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Published inFrontiers in surgery Vol. 9; p. 1049513
Main Authors Zhang, Yuke, Liu, Liting, Liu, Kai, Wang, Meiying, Su, Xiulan, Wang, Jianzhong
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 06.01.2023
Subjects
cartilage degeneration
circular RNA
competitive endogenous RNA
exosomes
osteoarthritis
RNA binding protein
Surgery
competitive endogenous RNA
circular RNA
exosomes
osteoarthritis
RNA binding protein
N6-methyladenosine
cartilage degeneration
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Summary:Osteoarthritis (OA) causes joint pain, stiffness, and dysfunction in middle-aged and older adults; however, its pathogenesis remains unclear. Circular RNAs (circRNAs) are differentially expressed in patients with OA and participate in a multigene, multitarget regulatory network. CircRNAs are involved in the development of OA through inflammatory responses, including proliferation, apoptosis, autophagy, differentiation, oxidative stress, and mechanical stress. Most circRNAs are used as intracellular miRNA sponges in chondrocytes, endplate chondrocytes, mesenchymal stem cells, synoviocytes, and macrophages to promote the progression of OA. However, a small portion of circRNAs participates in the pathogenesis of OA by intracellular mechanisms, such as protein binding, methylation, or intercellular exosome pathways. In this sense, circRNAs might serve as potential novel biomarkers and therapeutic targets for OA.
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Specialty Section: This article was submitted to Orthopedic Surgery, a section of the journal Frontiers in Surgery
Edited by: Qiling Yuan, Xi'an Jiaotong University, China
Reviewed by: Yu Kuan Tang, Guangzhou Panyu Central Hospital, China Binglin Yue, Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization Key Laboratory of Sichuan Province, China
These authors have contributed equally to this work and share first authorship
ISSN:2296-875X
2296-875X
DOI:10.3389/fsurg.2022.1049513