Visceral and Subcutaneous Fat Quality and Cardiometabolic Risk

• Published in: JACC. Cardiovascular imaging Vol. 6; no. 7; pp. 762 - 771
• Main Authors: Rosenquist, Klara J., MD, Pedley, Alison, PhD, Massaro, Joseph M., PhD, Therkelsen, Kate E., BA, Murabito, Joanne M., MD, ScM, Hoffmann, Udo, MD, MPH, Fox, Caroline S., MD, MPH
• Format: Journal Article
• Language: English
• Published: United States 01.07.2013
• Subjects: Adiposity; Adult; Cardiovascular; Female; Humans; Intra-Abdominal Fat - diagnostic imaging; Intra-Abdominal Fat - physiopathology; Linear Models; Logistic Models; Male; Metabolic Syndrome - diagnostic imaging; Metabolic Syndrome - etiology; Metabolic Syndrome - physiopathology; Middle Aged; Multidetector Computed Tomography; Multivariate Analysis; Odds Ratio; Predictive Value of Tests; Risk Factors; Sex Factors; Subcutaneous Fat - diagnostic imaging; Subcutaneous Fat - physiopathology; computed tomography; computed tomography imaging; Hounsfield unit; OR; body mass index; high-density lipoprotein; SAT; VAT; odds ratio; MDCT; HU; epidemiology; CT; HDL; HOMA-IR; homeostatic model assessment insulin resistance; multidetector computed tomography; subcutaneous adipose tissue; risk factors; FPG; fasting plasma glucose; obesity; BMI; visceral adipose tissue
• ISSN: 1936-878X; 1876-7591
• DOI: 10.1016/j.jcmg.2012.11.021

Objectives The aim of this study was to evaluate whether computed tomography (CT) attenuation, as a measure of fat quality, is associated with cardiometabolic risk factors above and beyond fat quantity. Background Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) are pathogenic fat depots associated with cardiometabolic risk. Adipose tissue attenuation in CT images is variable, similar to adipose tissue volume. However, whether the quality of abdominal fat attenuation is associated with cardiometabolic risk independent of the quantity is uncertain. Methods Participants were drawn from the Framingham Heart Study CT substudy. The VAT and SAT volumes were acquired by semiquantitative assessment. Fat quality was measured by CT attenuation and recorded as mean Hounsfield unit (HU) within each fat depot. Sex-specific linear and logistic multivariable regression models were used to assess the association between standard deviation (SD) decrease in HU and each risk factor. Results Lower CT attenuation of VAT and SAT was correlated with higher body mass index levels in both sexes. Risk factors were generally more adverse with decreasing HU values. For example, in women, per 1 SD decrease in VAT HU, the odds ratio (OR) was increased for hypertension (OR: 1.80), impaired fasting glucose (OR: 2.10), metabolic syndrome (OR: 3.65), and insulin resistance (OR: 3.36; all p < 0.0001). In models that further adjusted for VAT volume, impaired fasting glucose, metabolic syndrome, and insulin resistance remained significant. Trends were similar but less pronounced for SAT and for men. There was evidence of an interaction between HU and fat volume among both women and men. Conclusions Lower CT attenuation of VAT and SAT is associated with adverse cardiometabolic risk above and beyond total adipose tissue volume. Qualitative indices of abdominal fat depots may provide insight regarding cardiometabolic risk independent of fat quantity.