Cyclin D1 promotes tumor cell invasion and metastasis by cytoplasmic mechanisms

Amplification of cyclin D1 is a frequent alteration in many cancers of different type and origin. We recently described a novel regulatory axis involving cyclin D1 in the regulation of tumor invasion and metastasis. Membrane-associated cyclin D1-CDK4 complexes promote activation of the small GTPase...

Full description

Saved in:
Bibliographic Details
Published inMolecular & cellular oncology Vol. 3; no. 5; p. e1203471
Main Authors Fusté, Noel P., Ferrezuelo, Francisco, Garí, Eloi
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 02.09.2016
Subjects
Author's View
Cdk4
cell invasion
cyclin D1
metastasis
paxillin
Rac1
paxillin
cyclin D1
Rac1
cell invasion
Cdk4
metastasis
Online AccessGet full text

Cover

More Information
Summary:Amplification of cyclin D1 is a frequent alteration in many cancers of different type and origin. We recently described a novel regulatory axis involving cyclin D1 in the regulation of tumor invasion and metastasis. Membrane-associated cyclin D1-CDK4 complexes promote activation of the small GTPase RAC1 through phosphorylation of the regulatory protein paxillin.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2372-3556
2372-3556
DOI:10.1080/23723556.2016.1203471