Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans

Physical exercise has emerged as an alternative treatment for patients with depressive disorder. Recent animal studies show that exercise protects from depression by increased skeletal muscle kynurenine aminotransferase (KAT) expression which shifts the kynurenine metabolism away from the neurotoxic...

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Published inAmerican Journal of Physiology: Cell Physiology Vol. 310; no. 10; pp. C836 - C840
Main Authors Schlittler, Maja, Goiny, Michel, Agudelo, Leandro Z., Venckunas, Tomas, Brazaitis, Marius, Skurvydas, Albertas, Kamandulis, Sigitas, Ruas, Jorge L., Erhardt, Sophie, Westerblad, Håkan, Andersson, Daniel C.
Format Journal Article
LanguageEnglish
Published United States American Physiological Society 15.05.2016
Subjects
Exercise
Exercise - physiology
Gene expression
Humans
Kynurenic Acid - blood
Male
Mental depression
Metabolism
Muscle, Skeletal - physiology
Musculoskeletal system
Physical Conditioning, Human - methods
Physical Conditioning, Human - physiology
Physical Endurance - physiology
Protein expression
Transaminases - metabolism
Up-Regulation - physiology
Young Adult
endurance exercise
kynurenine aminotransferases
skeletal muscle
kynurenic acid
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Summary:Physical exercise has emerged as an alternative treatment for patients with depressive disorder. Recent animal studies show that exercise protects from depression by increased skeletal muscle kynurenine aminotransferase (KAT) expression which shifts the kynurenine metabolism away from the neurotoxic kynurenine (KYN) to the production of kynurenic acid (KYNA). In the present study, we investigated the effect of exercise on kynurenine metabolism in humans. KAT gene and protein expression was increased in the muscles of endurance-trained subjects compared with untrained subjects. Endurance exercise caused an increase in plasma KYNA within the first hour after exercise. In contrast, a bout of high-intensity eccentric exercise did not lead to increased plasma KYNA concentration. Our results show that regular endurance exercise causes adaptations in kynurenine metabolism which can have implications for exercise recommendations for patients with depressive disorder.
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ISSN:0363-6143
1522-1563
1522-1563
DOI:10.1152/ajpcell.00053.2016