Regulation of Arabidopsis MAPKKK18 by ABI1 and SnRK2, components of the ABA signaling pathway

• Published in: Plant signaling & behavior Vol. 11; no. 4; p. e1139277
• Main Authors: Tajdel, Małgorzata, Mituła, Filip, Ludwików, Agnieszka
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.01.2016
• Subjects: ABA signaling; ABI1; Abscisic Acid - metabolism; Addendum; Arabidopsis - metabolism; Arabidopsis Proteins - metabolism; Arabidopsis thaliana; MAP kinase cascade; MAP Kinase Kinase Kinases - metabolism; MAPKKK18; Phosphoprotein Phosphatases - metabolism; PP2C; Protein Binding; Protein-Serine-Threonine Kinases - metabolism; Signal Transduction; SnRK2; UPS; ABA signaling; Arabidopsis thaliana; MAPKKK18; PP2C; ABI1; UPS; SnRK2; MAP kinase cascade
• ISSN: 1559-2316; 1559-2324; 1559-2324
• DOI: 10.1080/15592324.2016.1139277

The plant hormone abscisic acid (ABA), a key regulator in many crucial developmental and physiological processes, recruits diverse components into precisely regulated signaling network. We recently discovered that MAPKKK18, an ABA-activated kinase, is regulated by the protein phosphatase type 2C (PP2C) ABI1 and the kinase SnRK2.6, both components of the ABA core signaling pathway. ABI1 acts to inhibit MAPKKK18 kinase activity, but also affects MAPKKK18 protein turnover via the ubiquitin-proteasome pathway. SnRK2.6 kinase also seems to be important for the regulation of MAPKKK18 function. In this review we summarize the mechanisms that are exclusively involved in MAPKKK18 kinase regulation and that ensure specificity in its activation.