Engineering antigen-specific immunological tolerance

Highlights • B cell tolerance can occur by clustering the B cell receptor with certain B cell-surface receptors. • T cell tolerance can occur by antigen presentation from dendritic cells without co-stimulation. • Antigen from apoptotic debris is presented by antigen-presenting cells tolerogenically....

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Bibliographic Details
Published inCurrent opinion in immunology Vol. 35; pp. 80 - 88
Main Authors Kontos, Stephan, Grimm, Alizée J, Hubbell, Jeffrey A
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2015
Subjects
Allergy and Immunology
Animals
Antigen Presentation
Apoptosis
B-Lymphocytes - immunology
Epitopes - metabolism
Humans
Peripheral Tolerance
Protein Engineering
Receptor Cross-Talk
Receptors, Antigen, B-Cell - metabolism
T-Cell Antigen Receptor Specificity
T-Lymphocytes - immunology
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Summary:Highlights • B cell tolerance can occur by clustering the B cell receptor with certain B cell-surface receptors. • T cell tolerance can occur by antigen presentation from dendritic cells without co-stimulation. • Antigen from apoptotic debris is presented by antigen-presenting cells tolerogenically. • Engineering systems can mimic antigen from apoptotic debris.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
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USDOE Office of Science - Office of Basic Energy Sciences - Materials Sciences and Engineering Division
AC02-06CH11357
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2015.05.005