Bullous pemphigoid: The role of type 2 inflammation in its pathogenesis and the prospect of targeted therapy

• Published in: Frontiers in immunology Vol. 14; p. 1115083
• Main Authors: Zhang, Luyao, Chen, Zihua, Wang, Lanting, Luo, Xiaoqun
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 16.02.2023
• Subjects: Aged; Autoimmune Diseases; bullous pemphigoid; Drug-Related Side Effects and Adverse Reactions; eosinophils; Humans; Immunity, Innate; immunoglobulin E; Immunology; Inflammation; Lymphocytes; Pemphigoid, Bullous; targeted therapy; type 2 inflammation; targeted therapy; eosinophils; bullous pemphigoid; immunoglobulin E; type 2 inflammation

Bullous pemphigoid (BP) is an autoimmune disease that mainly occurs in the elderly, severely affecting their health and life quality. Traditional therapy for BP is mainly based on the systemic use of corticosteroids, but long-term use of corticosteroids results in a series of side effects. Type 2 in...