Setup and data analysis for functional magnetic resonance imaging of awake cat visual cortex

Functional magnetic resonance imaging（fMRI）is one of the most commonly used methods in cognitive neuroscience on humans.In recent decades,fMRI has also been used in the awake monkey experiments to localize functional brain areas and to compare the functional differences between human and monkey brai...

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Published inNeuroscience bulletin Vol. 29; no. 5; pp. 588 - 602
Main Authors Ma, Manxiu, Qian, Chencan, Li, Yanxia, Zuo, Zhentao, Liu, Zuxiang
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2013
Subjects
Anatomy
Anesthesiology
Animals
Biomedical and Life Sciences
Biomedicine
Brain Mapping - methods
Cats - physiology
Human Physiology
Image Interpretation, Computer-Assisted - methods
Magnetic Resonance Imaging - methods
Neurology
Neurosciences
Original
Original Article
Pain Medicine
Photic Stimulation
Visual Cortex - physiology
Wakefulness
功能性磁共振成像
功能磁共振成像
实验设计
数据分析
猫
视觉皮层
认知神经科学
设置
non-rigid motion
motion correction
functional magnetic resonance imaging
cat
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Summary:Functional magnetic resonance imaging（fMRI）is one of the most commonly used methods in cognitive neuroscience on humans.In recent decades,fMRI has also been used in the awake monkey experiments to localize functional brain areas and to compare the functional differences between human and monkey brains.Several procedures and paradigms have been developed to maintain proper head fixation and to perform motion control training.In this study,we extended the application of fMRI to awake cats without training,receiving a flickering checkerboard visual stimulus projected to a screen in front of them in a block-design paradigm.We found that body movement-induced non-rigid motion introduced artifacts into the functional scans,especially those around the eye and neck.To correct for these artifacts,we developed two methods：one for general experimental design,and the other for studies of whether a checkerboard task could be used as a localizer to optimize the motioncorrection parameters.The results demonstrated that,with proper animal fixation and motion correction procedures,it is possible to perform fMRI experiments with untrained awake cats.
Bibliography:Functional magnetic resonance imaging（fMRI）is one of the most commonly used methods in cognitive neuroscience on humans.In recent decades,fMRI has also been used in the awake monkey experiments to localize functional brain areas and to compare the functional differences between human and monkey brains.Several procedures and paradigms have been developed to maintain proper head fixation and to perform motion control training.In this study,we extended the application of fMRI to awake cats without training,receiving a flickering checkerboard visual stimulus projected to a screen in front of them in a block-design paradigm.We found that body movement-induced non-rigid motion introduced artifacts into the functional scans,especially those around the eye and neck.To correct for these artifacts,we developed two methods：one for general experimental design,and the other for studies of whether a checkerboard task could be used as a localizer to optimize the motioncorrection parameters.The results demonstrated that,with proper animal fixation and motion correction procedures,it is possible to perform fMRI experiments with untrained awake cats.
functional magnetic resonance imaging cat motion correction non-rigid motion
31-1975/R
ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1673-7067
1995-8218
DOI:10.1007/s12264-013-1349-4