Fur functions as an activator of T6SS-mediated bacterial dominance and virulence in Aeromonas hydrophila
, a ubiquitous bacterium in aquatic habitats with broad host ranges, has earned the nickname of a 'Jack-of-all-trades'. However, there is still a limited understanding of the mechanism of how this bacterium fit the competition with other species in dynamic surroundings. The type VI secreti...
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Published in | Frontiers in microbiology Vol. 13; p. 1099611 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
08.02.2023
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Subjects | |
Online Access | Get full text |
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Summary: | , a ubiquitous bacterium in aquatic habitats with broad host ranges, has earned the nickname of a 'Jack-of-all-trades'. However, there is still a limited understanding of the mechanism of how this bacterium fit the competition with other species in dynamic surroundings. The type VI secretion system (T6SS) is macromolecular machinery found in Gram-negative bacteria's cell envelope that is responsible for bacterial killing and/or pathogenicity toward different host cells. In this study, the depression of
T6SS under iron-limiting conditions was detected. The ferric uptake regulator (Fur) was then found to act as an activator of T6SS by directly binding to the Fur box region in
A promoter in the T6SS gene cluster. The transcription of
A was repressed in Δ
. Moreover, the inactivation of Fur resulted in considerable defects in the interbacterial competition activity and pathogenicity of
and
. These findings provide the first direct evidence that Fur positively regulates the expression and functional activity of T6SS in Gram-negative bacteria and will help to understand the fascinating mechanism of competitive advantage for
in different ecological niches. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Infectious Agents and Disease, a section of the journal Frontiers in Microbiology Edited by: Maoda Pang, Jiangsu Academy of Agricultural Sciences (JAAS), China Reviewed by: Salih Kumru, Recep Tayyip Erdoğan University, Türkiye; Lixing Huang, Jimei University, China; Ruojun Wang, Princeton University, United States |
ISSN: | 1664-302X 1664-302X |
DOI: | 10.3389/fmicb.2022.1099611 |