Fur functions as an activator of T6SS-mediated bacterial dominance and virulence in Aeromonas hydrophila

, a ubiquitous bacterium in aquatic habitats with broad host ranges, has earned the nickname of a 'Jack-of-all-trades'. However, there is still a limited understanding of the mechanism of how this bacterium fit the competition with other species in dynamic surroundings. The type VI secreti...

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Published inFrontiers in microbiology Vol. 13; p. 1099611
Main Authors Li, Jihong, Wu, Zhihao, Hou, Yuting, Zhang, Yong-An, Zhou, Yang
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 08.02.2023
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Summary:, a ubiquitous bacterium in aquatic habitats with broad host ranges, has earned the nickname of a 'Jack-of-all-trades'. However, there is still a limited understanding of the mechanism of how this bacterium fit the competition with other species in dynamic surroundings. The type VI secretion system (T6SS) is macromolecular machinery found in Gram-negative bacteria's cell envelope that is responsible for bacterial killing and/or pathogenicity toward different host cells. In this study, the depression of T6SS under iron-limiting conditions was detected. The ferric uptake regulator (Fur) was then found to act as an activator of T6SS by directly binding to the Fur box region in A promoter in the T6SS gene cluster. The transcription of A was repressed in Δ . Moreover, the inactivation of Fur resulted in considerable defects in the interbacterial competition activity and pathogenicity of and . These findings provide the first direct evidence that Fur positively regulates the expression and functional activity of T6SS in Gram-negative bacteria and will help to understand the fascinating mechanism of competitive advantage for in different ecological niches.
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This article was submitted to Infectious Agents and Disease, a section of the journal Frontiers in Microbiology
Edited by: Maoda Pang, Jiangsu Academy of Agricultural Sciences (JAAS), China
Reviewed by: Salih Kumru, Recep Tayyip Erdoğan University, Türkiye; Lixing Huang, Jimei University, China; Ruojun Wang, Princeton University, United States
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2022.1099611