Fibrinogen is an Independent Marker for Thoracic Aortic Atherosclerosis

• Published in: The American journal of cardiology Vol. 81; no. 3; pp. 321 - 326
• Main Authors: Tribouilloy, Christophe, Peltier, Marcel, Colas, Laurent, Senni, Michele, Ganry, Olivier, Rey, Jean-Luc, Lesbre, Jean-Philippe
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.02.1998; Elsevier; Elsevier Limited
• Subjects: Adult; Aged; Aorta, Thoracic; Aortic Diseases - blood; Arteriosclerosis - blood; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Biomarkers - blood; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular disease; Coronary Angiography; Female; Fibrinogen - analysis; Humans; Male; Medical sciences; Middle Aged; Prospective Studies; Risk Factors; Sonography; Vascular disease; Thoracic aorta; Human; Echocardiography; Atherosclerosis; Risk factor; Fibrinogen; Cardiovascular disease; Esophageal route; Blood plasma
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/S0002-9149(97)00900-4

The fibrinogen level is an independent risk factor for coronary events and stroke, but no detailed data are available concerning fibrinogen and atherosclerotic disease of the thoracic aorta. This prospective study using multiplane transesophageal echocardiography examined the relation between atherosclerotic thoracic aortic plaque and fibrinogen level. One-hundred forty-eight patients (65 ± 11 years) with valvular heart disease underwent multiplane transesophageal echocardiography and coronary angiography. We measured plasma fibrinogen level for each patient and recorded the following cardiovascular risk factors: age, sex, systemic hypertension, history of smoking, hypercholesterolemia, diabetes mellitus, body mass index, and family history of coronary artery disease (CAD). Patients with thoracic aortic plaque had a higher level of plasma fibrinogen (p = 0.0001), were older (p = 0.0001), and had significantly more risk factors: history of smoking (p = 0.009), hypertension (p = 0.008), hypercholesterolemia (p = 0.0001), diabetes mellitus (p = 0.01), and family history of CAD (p = 0.003). Multivariate logistic regression analysis of fibrinogen level and risk factors revealed 4 independent predictors of thoracic aortic plaque: fibrinogen, age, hypercholesterolemia, and history of smoking. Fibrinogen was also an independent predictor of CAD. There was a relation between fibrinogen levels and the severity of aortic atherosclerosis (r = 0.46; p = 0.0001) and the severity of CAD (r = 0.30; p = 0.0001). This prospective study indicates that fibrinogen is an independent marker for thoracic aortic plaque related to the severity of thoracic aortic atherosclerosis and confirms that fibrinogen constitutes an independent marker for CAD related to the severity of angiographically evaluated coronary atherosclerosis.