RNA capping by mitochondrial and multi-subunit RNA polymerases

Recently, it was found that bacterial and eukaryotic transcripts are capped with cellular cofactors installed by their respective RNA polymerases (RNAPs) during transcription initiation. We now show that mitochondrial RNAP efficiently caps transcripts with ADP - containing cofactors. However, a func...

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Bibliographic Details
Published inTranscription Vol. 9; no. 5; pp. 292 - 297
Main Authors Julius, Christina, Riaz-Bradley, Amber, Yuzenkova, Yulia
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 20.10.2018
Subjects
Adenosine Diphosphate - genetics
Adenosine Diphosphate - metabolism
Bacteria - enzymology
Coenzyme A - genetics
Coenzyme A - metabolism
dephospho coenzymeA
DNA-Directed RNA Polymerases - genetics
DNA-Directed RNA Polymerases - metabolism
Eukaryota - enzymology
FAD
Flavin-Adenine Dinucleotide - metabolism
Humans
Mitochondria - enzymology
mitochondrial RNA polymerase
Molecular Conformation
NAD
NAD - genetics
NAD - metabolism
non-canonical capping
Point-of-View
Promoter Regions, Genetic
RNA - genetics
RNA - metabolism
RNA capping
RNA Caps - chemistry
RNA polymerase
transcription
Transcription, Genetic
UDP-GlcNAc
NAD
UDP-GlcNAc
non-canonical capping
dephospho coenzymeA
transcription
FAD
mitochondrial RNA polymerase
RNA polymerase
RNA capping
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Summary:Recently, it was found that bacterial and eukaryotic transcripts are capped with cellular cofactors installed by their respective RNA polymerases (RNAPs) during transcription initiation. We now show that mitochondrial RNAP efficiently caps transcripts with ADP - containing cofactors. However, a functional role of universal RNAP - catalysed capping is not yet clear.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:2154-1264
2154-1272
DOI:10.1080/21541264.2018.1456258