Meteorin-like/Metrnl, a novel secreted protein implicated in inflammation, immunology, and metabolism: A comprehensive review of preclinical and clinical studies

Meteorin-like, also known as Metrnl, Meteorin-β, Subfatin, and Cometin, is a novel secreted protein exerting pleiotropic effects on inflammation, immunology, and metabolism. Earlier research on this hormone focused on regulating energy expenditure and glucose homeostasis. Consequently, several studi...

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Published inFrontiers in immunology Vol. 14; p. 1098570
Main Authors Li, Zhuoqi, Gao, Ziyu, Sun, Tao, Zhang, Shipeng, Yang, Shengnan, Zheng, Meilin, Shen, Hui
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 24.02.2023
Subjects
Adipokines
Animals
Biomarkers
bone
heart
Humans
immunity
Immunology
Inflammation
metabolism
Metrnl
Nerve Growth Factors - metabolism
Obesity
inflammation
bone
metabolism
immunity
diabetes
Metrnl
heart
obesity
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Summary:Meteorin-like, also known as Metrnl, Meteorin-β, Subfatin, and Cometin, is a novel secreted protein exerting pleiotropic effects on inflammation, immunology, and metabolism. Earlier research on this hormone focused on regulating energy expenditure and glucose homeostasis. Consequently, several studies attempted to characterize the molecule mechanism of Metrnl in glucose metabolism and obesity-related disorders but reported contradictory clinical results. Recent studies gradually noticed its multiple protective functions in inflammatory immune regulations and cardiometabolic diseases, such as inducing macrophage activation, angiogenesis, tissue remodeling, bone formation, and preventing dyslipidemias. A comprehensive understanding of this novel protein is essential to identify its significance as a potential therapeutic drug or a biomarker of certain diseases. In this review, we present the current knowledge on the physiology of Metrnl and its roles in inflammation, immunology, and metabolism, including animal/cell interventional preclinical studies and human clinical studies. We also describe controversies regarding the data of circulation Metrnl in different disease states to determine its clinical application better.
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Reviewed by: Jing Li, Nanjing University, China; Dina H. Kassem, Ain Shams University, Egypt
This article was submitted to Cytokines and Soluble Mediators in Immunity, a section of the journal Frontiers in Immunology
Edited by: Yujing Zhang, Nanjing University, China
These authors have contributed equally to this work
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1098570