The impact of pain and nocturnal cramps on sleep quality in Charcot Marie Tooth disease: a case-control study

• Published in: Sleep science (Sao Paulo, Brazil) Vol. 15; no. 1; pp. 41 - 46
• Main Authors: Souza, Cynthia Coelho, Vallim, Julia Ribeiro da Silva, Neves, Eduardo Luis de Aquino, Nunes, Paula Santos, Costa, Iandra Maria Pinheiro de França, Barreto, Lidiane Carine Lima Santos, Garcez, Catarina Andrade, Araujo, Adriano Antunes de Souza
• Format: Journal Article
• Language: English
• Published: Brazil Brazilian Association of Sleep and Latin American Federation of Sleep 01.01.2022; Thieme Revinter Publicações Ltda
• Subjects: actigraphy; charcot-marie-tooth disease; chronic pain; nervous system; Original; polyneuropathies; sleep; Actigraphy; Sleep; Nervous System; Polyneuropathies; Charcot-Marie-Tooth disease; Chronic Pain
• ISSN: 1984-0659; 1984-0063
• DOI: 10.5935/1984-0063.20210025

Charcot-Marie-Tooth disease is an inherited neuropathy that presents two main forms - type 1 and type 2 -, differentiated by the speed of the nervous conduction. Our goal was to assess sleep in Charcot-Marie-Tooth disease and its relationship with pain perception and nocturnal cramps. This was a case-control study. The case group was composed of 10 volunteers diagnosed with the type 1 and 23 with the type 2. The control group was composed of 22 individuals from the same family matched by age and gender. Volunteers underwent clinical screening to assess the presence of nocturnal cramps and filled the brief pain inventory, the Chalder fatigue scale, the Epworth sleepiness scale, and the Pittsburgh sleep quality index. Sleep was evaluated by actigraphy. Type 2 patients presented a more severe perception of pain and fatigue, more time spend awake after sleep onset, and had lower sleep efficiency. The individuals who reported nocturnal cramps also had worse perception of pain, reduced sleep latency, and increased sleep fragmentation. The Charcot-Marie-Tooth type 2 was related with worse sleep quality, perception of pain, and fatigue and these parameters were negatively related.