Prenatal administration of lipopolysaccharide induces sex-dependent changes in glutamic acid decarboxylase and parvalbumin in the adult rat brain

• Published in: Neuroscience Vol. 287; pp. 78 - 92
• Main Authors: Basta-Kaim, A, Fijał, K, Ślusarczyk, J, Trojan, E, Głombik, K, Budziszewska, B, Leśkiewicz, M, Regulska, M, Kubera, M, Lasoń, W, Wędzony, K
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 26.02.2015
• Subjects: Animals; Cell Count; Exploratory Behavior - drug effects; Female; Glutamate Decarboxylase - metabolism; glutamic acid decarboxylase (GAD67); Hippocampus - drug effects; Hippocampus - enzymology; Hippocampus - metabolism; Immunohistochemistry; Lipopolysaccharides - toxicity; Male; neurodevelopmental model of schizophrenia; Neurology; parvalbumin (PV); Parvalbumins - metabolism; Prefrontal Cortex - drug effects; Prefrontal Cortex - enzymology; Prefrontal Cortex - metabolism; Pregnancy; Prenatal Exposure Delayed Effects - metabolism; Prepulse Inhibition - drug effects; Rats; Rats, Wistar; Schizophrenia - chemically induced; Schizophrenia - metabolism; Schizophrenia - physiopathology; sensorimotor gating; Sex Factors; Social Behavior; social interaction; interleukin 1β; PP; glutamic acid decarboxylase (GAD67); DG; tumor necrosis factor α; PPI; phosphate-buffered saline; integrated optical density; LPS; vehicle; interleukin 6; MK-801; prepulse; Tris-buffered saline; analysis of variance; ANOVA; interleukin 2; sodium dodecyl sulfate; social interaction; parvalbumin (PV); sensorimotor gating; IOD; PBS; SDS; TBS; estrogen receptor; neurodevelopmental model of schizophrenia; TBST; gamma-aminobutyric acid; IL-2; Tris-buffered saline containing 0.1% Tween-20; prepulse inhibition; GAD67; IL-1β; dizocilpine; ER; IL-6; dentate gyrus; TNF-α; GABA; VEH; SEM; standard error of the mean; lipopolysaccharide; GAPDH; glutamate decarboxylase; glyceraldehyde 3-phosphate dehydrogenase
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2014.12.013

Highlights • Prenatal LPS-treatment causes behavioral disturbances. • Prenatal LPS-treatment decreases GAD67- and PV-positive neurons. • GABA-related changes are sex-dependent.