DNA-functionalized gold nanoparticles: Modification, characterization, and biomedical applications

With the development of technologies based on gold nanoparticles (AuNPs), bare AuNPs cannot meet the increasing requirements of biomedical applications. Modifications with different functional ligands are usually needed. DNA is not only the main genetic material, but also a good biological material,...

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Published inFrontiers in chemistry Vol. 10; p. 1095488
Main Authors Ma, Xiaoyi, Li, Xiaoqiang, Luo, Gangyin, Jiao, Jin
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 13.12.2022
Subjects
biosensor
Chemistry
DNA hybridization
DNA modification
gold nanoparticles
therapy
DNA modification
biosensor
DNA hybridization
gold nanoparticles
therapy
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Summary:With the development of technologies based on gold nanoparticles (AuNPs), bare AuNPs cannot meet the increasing requirements of biomedical applications. Modifications with different functional ligands are usually needed. DNA is not only the main genetic material, but also a good biological material, which has excellent biocompatibility, facile design, and accurate identification. DNA is a perfect ligand candidate for AuNPs, which can make up for the shortcoming of bare AuNPs. DNA-modified AuNPs (DNA-AuNPs) have exciting features and bright prospects in many fields, which have been intensively investigated in the past decade. In this review, we summarize the various approaches for the immobilization of DNA strands on the surface of AuNPs. Representative studies for biomedical applications based on DNA-AuNPs are also discussed. Finally, we present the challenges and future directions.
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Reviewed by: Guangfeng Wang, Anhui Normal University, China
Edited by: Xiaoli Zhu, Tongji University, China
Chengmin Jiang, American Society for Biochemistry and Molecular Biology, United States
This article was submitted to Analytical Chemistry, a section of the journal Frontiers in Chemistry
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2022.1095488