Young adolescents with autism show abnormal joint attention network: A gaze contingent fMRI study

• Published in: NeuroImage clinical Vol. 14; no. C; pp. 112 - 121
• Main Authors: Oberwelland, E, Schilbach, L, Barisic, I, Krall, S C, Vogeley, K, Fink, G R, Herpertz-Dahlmann, B, Konrad, K, Schulte-Rüther, M
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier 01.01.2017
• Subjects: Adolescent; Attention Deficit Disorder with Hyperactivity - etiology; Autistic Disorder - complications; Autistic Disorder - diagnostic imaging; Autistic Disorder - psychology; Brain Mapping; Child; Eye-tracking; Familiarity; Female; Fixation, Ocular - physiology; Functional magnetic resonance imaging; Humans; Image Processing, Computer-Assisted; Interpersonal Relations; Magnetic Resonance Imaging; Male; Oxygen - blood; Regular; Social Behavior; Social interaction; Statistics, Nonparametric; Superior temporal sulcus; Temporoparietal junction; Functional magnetic resonance imaging; Superior temporal sulcus; Familiarity; Social interaction; Eye-tracking; Temporoparietal junction
• ISSN: 2213-1582; 2213-1582
• DOI: 10.1016/j.nicl.2017.01.006

Behavioral research has revealed deficits in the development of joint attention (JA) as one of the earliest signs of autism. While the neural basis of JA has been studied predominantly in adults, we recently demonstrated a protracted development of the brain networks supporting JA in typically developing children and adolescents. The present eye-tracking/fMRI study now extends these findings to adolescents with autism. Our results show that in adolescents with autism JA is subserved by abnormal activation patterns in brain areas related to social cognition abnormalities which are at the core of ASD including the STS and TPJ, despite behavioral maturation with no behavioral differences. Furthermore, in the autism group we observed increased neural activity in a network of social and emotional processing areas during interactions with their mother. Moreover, data indicated that less severely affected individuals with autism showed higher frontal activation associated with self-initiated interactions. Taken together, this study provides first-time data of JA in children/adolescents with autism incorporating the interactive character of JA, its reciprocity and motivational aspects. The observed functional differences in adolescents ASD suggest that persistent developmental differences in the neural processes underlying JA contribute to social interaction difficulties in ASD.