The potential roles of JAK/STAT signaling in the progression of osteoarthritis

• Published in: Frontiers in endocrinology (Lausanne) Vol. 13; p. 1069057
• Main Authors: Zhou, Qingluo, Ren, Qun, Jiao, Linhui, Huang, Jishang, Yi, Jun, Chen, Jincai, Lai, Jinliang, Ji, Guanglin, Zheng, Tiansheng
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 24.11.2022
• Subjects: cartilage remodeling; Chondrocytes - metabolism; Endocrinology; Humans; inflammation; JAK/STAT pathway; Janus Kinases - metabolism; Janus Kinases - therapeutic use; osteoarthritis; Osteoarthritis - etiology; Osteoarthritis - metabolism; Signal Transduction - physiology; SOCS; STAT Transcription Factors - metabolism; STAT Transcription Factors - therapeutic use; SOCS; cartilage remodeling; inflammation; JAK/STAT pathway; osteoarthritis
• ISSN: 1664-2392; 1664-2392
• DOI: 10.3389/fendo.2022.1069057

Osteoarthritis (OA) is an age-related chronic progressive degenerative disease that induces persistent pain and disabilities. The development of OA is a complex process, and the risk factors are various, including aging, genetics, trauma and altered biomechanics. Inflammation and immunity play an important role in the pathogenesis of OA. JAK/STAT pathway is one of the most prominent intracellular signaling pathways, regulating cell proliferation, differentiation, and apoptosis. Inflammatory factors can act as the initiators of JAK/STAT pathway, which is implicated in the pathophysiological activity of chondrocyte. In this article, we provide a review on the importance of JAK/STAT pathway in the pathological development of OA. Potentially, JAK/STAT pathway becomes a therapeutic target for managing OA.