Lymphoid blast crisis of chronic myelogenous leukemia occurring more than 11 years after receiving an allogeneic bone marrow transplant for chronic myelogenous leukemia in myeloid blast crisis at onset

• Published in: Bone marrow transplantation (Basingstoke) Vol. 31; no. 3; pp. 211 - 213
• Main Authors: FUKUNO, K, TSURUMI, H, YAMADA, T, OYAMA, M, MATSUYAMA, T, TERAKURA, S, KODERA, Y, MORIWAKI, H
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.02.2003
• Subjects: Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Blast crisis; Blast Crisis - diagnosis; Blast Crisis - pathology; Bone marrow; Bone Marrow Transplantation; Bone marrow, stem cells transplantation. Graft versus host reaction; Care and treatment; Case studies; Chronic myeloid leukemia; Crises; Diagnosis; Follow-Up Studies; Health aspects; Hematologic and hematopoietic diseases; Histocompatibility antigen HLA; Humans; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Methods; Myeloid leukemia; Risk factors; Siblings; Stem cell transplantation; Time Factors; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Transplantation; Transplantation Chimera; Transplantation, Homologous; Japan; Human; Relapse; bone marrow transplant; late relapse; Stem cell; Hematopoietic cell; Clinical form; Homograft; Male; chronic myelogenous leukemia; Malignant hemopathy; Blast transformation; Case study; Myeloproliferative syndrome; Chronic; Treatment; lymphoid blast crisis; acute lymphoblastic leukemia; Chronic myelocytic leukemia; Bone marrow; Graft; Complication; Lymphocyte
• ISSN: 0268-3369; 1476-5365
• DOI: 10.1038/sj.bmt.1703820

A 25-year-old male developed lymphoid blast crisis (BC) of chronic myelogenous leukemia (CML) more than 11 years after receiving an allogeneic bone marrow transplant (alloBMT) for CML with myeloid BC at presentation from his HLA-identical brother. The lymphoid BC of CML probably occurred without a preceding chronic phase of CML. This case illustrates the difficulties involved in determining the appropriate length of follow-up after alloBMT.