The involvement of spontaneous brain activity in natural recovery from internet gaming disorder: A resting-state fMRI study

• Published in: Frontiers in psychiatry Vol. 14; p. 1093784
• Main Authors: Liu, Xiaoyue, Zheng, Yawen, Niculescu, Michelle, Liang, Qi, Yang, Ai, Dong, Guangheng, Gao, Zhonghui, Lin, Ping, Liu, Yanlong, Chen, Li, Xu, Danjun
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 21.02.2023
• Subjects: internet gaming disorder; natural recovery; Psychiatry; regional homogeneity; resting-state fMRI; reward function; natural recovery; internet gaming disorder; reward function; regional homogeneity; resting-state fMRI
• ISSN: 1664-0640; 1664-0640
• DOI: 10.3389/fpsyt.2023.1093784

Internet gaming disorder (IGD) can seriously impair an individual's physical and mental health. However, unlike the majority of those suffering from substance addiction, individuals with IGD may recover without any professional intervention. Understanding the brain mechanisms of natural recovery from IGD may provide new insight into how to prevent addiction and implement more targeted interventions. Sixty individuals with IGD were scanned by using a resting-state fMRI to assess brain region changes associated with IGD. After 1 year, 19 individuals with IGD no longer met the IGD criteria and were considered recovered (RE-IGD), 23 individuals still met the IGD criteria (PER-IGD), and 18 individuals left the study. The brain activity in resting state between 19 RE-IGD individuals and 23 PER-IGD individuals was compared by using regional homogeneity (ReHo). Additionally, brain structure and cue-craving functional MRIs were collected to further support the results in the resting-state. The resting-state fMRI results revealed that activity in brain regions responsible for reward and inhibitory control [including the orbitofrontal cortex (OFC), the precuneus and the dorsolateral prefrontal cortex (DLPFC)] was decreased in the PER-IGD individuals compared to RE-IGD individuals. In addition, significant positive correlations were found between mean ReHo values in the precuneus and self-reported craving scores for gaming, whether among the PER-IGD individuals or the RE-IGD individuals. Furthermore, we found similar results in that brain structure and cue-craving differences exist between the PER-IGD individuals and RE-IGD individuals, specifically in the brain regions associated with reward processing and inhibitory control (including the DLPFC, anterior cingulate gyrus, insula, OFC, precuneus, and superior frontal gyrus). These findings indicate that the brain regions responsible for reward processing and inhibitory control are different in PER-IGD individuals, which may have consequences on natural recovery. Our present study provides neuroimaging evidence that spontaneous brain activity may influence natural recovery from IGD.