Redox-sensitive synchronizing action of adenosine on transmitter release at the neuromuscular junction

• Published in: Neuroscience Vol. 248; pp. 699 - 707
• Main Authors: Tsentsevitsky, A, Kovyazina, I, Nikolsky, E, Bukharaeva, E, Giniatullin, R
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 17.09.2013
• Subjects: Acetylcholine - metabolism; adenosine; Adenosine - pharmacology; Animals; Antioxidants - pharmacology; Anura; In Vitro Techniques; kinetics of transmitter release; Motor Neurons - physiology; Neurology; neuromuscular junction; Neuromuscular Junction - drug effects; Neuromuscular Junction - metabolism; Neuromuscular Junction - physiology; Oxidation-Reduction; Rana ridibunda; reactive oxygen species; Reactive Oxygen Species - pharmacology; Receptor, Adenosine A1 - metabolism; redox modulation; release timing; Synaptic Transmission - physiology; N-cyclopentyl-adenosine; kinetics of transmitter release; quantal content; m; redox modulation; adenosine; NAC; N-acetyl-cysteine; CPA; MEPCs; neuromuscular junction; miniature end-plate currents; ROS; reactive oxygen species; 8-cyclopentyl dipropyixanthine; EPCs; DPCPX; end-plate currents; release timing
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2013.05.065

Highlights • Adenosine synchronizes transmitter release from motor nerve terminals. • The action of adenosine is abolished by oxidants but enhanced by the antioxidant. • Modulation of release timing was mediated by purinergic A1 receptors. • Adenosine also reduced the rise-time of multiquantal synaptic currents.