Absence of mutations in the ATM gene in forty-seven cases of sporadic breast cancer

• Published in: British Journal of Cancer Vol. 80; no. 12; pp. 1979 - 1981
• Main Authors: BEBB, D. G, YU, Z, CHEN, J, TELATAR, M, GELMON, K, PHILLIPS, N, GATTI, R. A, GLICKMAN, B. W
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.08.1999
• Subjects: Adult; Age of Onset; Aged; Ataxia Telangiectasia - genetics; Ataxia Telangiectasia Mutated Proteins; Biological and medical sciences; Breast Neoplasms - blood; Breast Neoplasms - genetics; Cell Cycle Proteins; DNA-Binding Proteins; Female; Genetic Carrier Screening; Gynecology. Andrology. Obstetrics; Humans; Mammary gland diseases; Medical sciences; Middle Aged; Mutation; Polymerase Chain Reaction; Protein-Serine-Threonine Kinases; Proteins - genetics; Regular; RNA - blood; Sensitivity and Specificity; Tumor Suppressor Proteins; Tumors; Canada; North America; America; Human; Immunopathology; Skin disease; Nervous system diseases; Cardiovascular disease; Malignant tumor; Epidemiology; Genetic disease; Vascular disease; Mammary gland diseases; Eye disease; Gene; Risk factor; Genetics; Ataxia telangiectasia; Mammary gland; Mutation; Public health
• ISSN: 0007-0920; 1476-5381; 1532-1827
• DOI: 10.1038/sj.bjc.6690630

Epidemiological evidence points to an increased risk of breast cancer in ataxia telangiectasia (AT) heterozygote women. Previous attempts to screen early onset or familial breast cancer patients failed to confirm an association. The issue of AT and late onset sporadic breast cancer remained unresolved. We screened 47 women who developed later onset, sporadic breast cancer for ataxia telangiectasia mutated (ATM) mutations. No mutations were found.