Comparison of the modified Singapore myocardial infarction registry risk score with GRACE 2.0 in predicting 1-year acute myocardial infarction outcomes

• Published in: Scientific reports Vol. 12; no. 1; p. 14270
• Main Authors: Sia, Ching-Hui, Zheng, Huili, Ko, Junsuk, Ho, Andrew Fu-Wah, Foo, David, Foo, Ling-Li, Lim, Patrick Zhan-Yun, Liew, Boon Wah, Chai, Ping, Yeo, Tiong-Cheng, Tan, Huay-Cheem, Chua, Terrance, Chan, Mark Yan-Yee, Tan, Jack Wei Chieh, Fox, Keith A. A., Bulluck, Heerajnarain, Hausenloy, Derek J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.08.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 692/308; 692/4019; 692/499; Heart attacks; Humanities and Social Sciences; Minority & ethnic groups; Mortality; Mortality risk; multidisciplinary; Myocardial infarction; Science; Science (multidisciplinary); Singapore
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-16523-6

Risk stratification plays a key role in identifying acute myocardial infarction (AMI) patients at higher risk of mortality. However, current AMI risk scores such as the Global Registry of Acute Coronary Events (GRACE) score were derived from predominantly Caucasian populations and may not be applicable to Asian populations. We previously developed an AMI risk score from the national-level Singapore Myocardial Infarction Registry (SMIR) confined to ST-segment elevation myocardial infarction (STEMI) patients and did not include non-STEMI (NSTEMI) patients. Here, we derived a modified SMIR risk score for both STEMI and NSTEMI patients and compared its performance to the GRACE 2.0 score for predicting 1-year all-cause mortality in our multi-ethnic population. The most significant predictor of 1-year all-cause mortality in our population using the GRACE 2.0 score was cardiopulmonary resuscitation on admission (adjusted hazards ratio [HR] 6.50), while the most significant predictor using the SMIR score was age 80–89 years (adjusted HR 7.78). Although the variables used in the GRACE 2.0 score and SMIR score were not exactly the same, the c-statistics for 1-year all-cause mortality were similar between the two scores (GRACE 2.0 0.841 and SMIR 0.865). In conclusion, we have shown that in a multi-ethnic Asian AMI population undergoing PCI, the SMIR score performed as well as the GRACE 2.0 score.