Effect of different revascularization times on intermediate-risk non-ST-elevation acute coronary syndrome

• Published in: Scientific reports Vol. 12; no. 1; p. 15714
• Main Authors: Kong, Xiangyong, Yin, Jun, Chen, Hongwu, Wu, Jiawei, Yu, Xiaofan, Zhou, Ningtian, Ma, Likun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.09.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 692/4019/2773; 692/4019/2776; Acute coronary syndromes; Heart attacks; Humanities and Social Sciences; multidisciplinary; Myocardial infarction; Patients; Risk factors; Science; Science (multidisciplinary); Thrombolysis
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-20185-9

Non-ST-elevation acute coronary syndrome (NSTE-ACS) is a specific type of acute coronary syndrome. We applied the Thrombolysis in Myocardial Infarction (TIMI) score for risk stratification of patient prognosis. There was uncertainty about the routine revascularization time in patients with intermediate-risk NSTE-ACS. A total of 2835 patients with intermediate-risk NSTE-ACS (TIMI score 3–4) included in the China Acute Myocardial Infarction Registry from November 2014 to January 2017 were analyzed according to the time window from symptom onset to revascularization: within 24 h, Group I (814/28.7%); within 24 to 48 h, Group II (526/18.6%); within 48 to 72 h, Group III (403/14.2%); and after 72 h, Group IV (1092/38.5%). Risk factors, management and in-hospital outcomes were analyzed in the four groups. The results of the chi-square test showed that there was a significant difference in the incidence of in-hospital major adverse cardiovascular events (MACEs) when revascularization was completed within 48 h than when it was completed after 48 h (P < 0.05). The results of revascularization within 48 h were similar, and the incidence of in-hospital MACEs was lower than when revascularization was completed after 48 h. The incidence of in-hospital MACEs among patients who underwent revascularization within 48 h is lower than that of patients who underwent revascularization after 48 h.