Clonal hematopoiesis: Mutation-specific adaptation to environmental change
Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion of genetically variant hematopoietic cells that increases exponentially with age and is associated with increased risks of cancers, cardiovascular disease, and other maladies. Here, we discuss how environmental c...
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Published in | Cell stem cell Vol. 29; no. 6; pp. 882 - 904 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
02.06.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion of genetically variant hematopoietic cells that increases exponentially with age and is associated with increased risks of cancers, cardiovascular disease, and other maladies. Here, we discuss how environmental contexts associated with CHIP, such as old age, infections, chemotherapy, or cigarette smoking, alter tissue microenvironments to facilitate the selection and expansion of specific CHIP mutant clones. Further, we consider major remaining gaps in knowledge, including intrinsic effects, clone size thresholds, and factors affecting clonal competition, that will determine future application of this field in transplant and preventive medicine. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-2 equal contribution MF, BT, and TW wrote the initial draft and made the figures and tables. KYK conceived the project, provided funding, and edited the final draft. EP and JD edited the initial and final drafts. Author Contributions |
ISSN: | 1934-5909 1875-9777 |
DOI: | 10.1016/j.stem.2022.05.006 |