Clonal hematopoiesis: Mutation-specific adaptation to environmental change

Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion of genetically variant hematopoietic cells that increases exponentially with age and is associated with increased risks of cancers, cardiovascular disease, and other maladies. Here, we discuss how environmental c...

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Bibliographic Details
Published inCell stem cell Vol. 29; no. 6; pp. 882 - 904
Main Authors Florez, Marcus A, Tran, Brandon T, Wathan, Trisha K, DeGregori, James, Pietras, Eric M, King, Katherine Y
Format Journal Article
LanguageEnglish
Published United States 02.06.2022
Subjects
Clonal Hematopoiesis - genetics
Hematopoiesis - genetics
Hematopoietic Stem Cells
Mutation - genetics
Risk Factors
clonal hematopoiesis
infection
inflammation
radiation
clonal competition
cancer
aging
chemotherapy
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Summary:Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion of genetically variant hematopoietic cells that increases exponentially with age and is associated with increased risks of cancers, cardiovascular disease, and other maladies. Here, we discuss how environmental contexts associated with CHIP, such as old age, infections, chemotherapy, or cigarette smoking, alter tissue microenvironments to facilitate the selection and expansion of specific CHIP mutant clones. Further, we consider major remaining gaps in knowledge, including intrinsic effects, clone size thresholds, and factors affecting clonal competition, that will determine future application of this field in transplant and preventive medicine.
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equal contribution
MF, BT, and TW wrote the initial draft and made the figures and tables. KYK conceived the project, provided funding, and edited the final draft. EP and JD edited the initial and final drafts.
Author Contributions
ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2022.05.006