POLE proofreading mutation, immune response and prognosis in endometrial cancer

Endometrial cancers (ECs) with POLE proofreading mutations are typified by ultramutation and excellent prognosis. We investigated whether these were related, and found that POLE-mutant ECs display a robust T cell response that corresponds to an enrichment of antigenic tumor neopeptides. Enhanced imm...

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Bibliographic Details
Published inOncoimmunology Vol. 5; no. 3; p. e1072675
Main Authors van Gool, Inge C., Bosse, Tjalling, Church, David N.
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 03.03.2016
Subjects
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DNA polymerase ϵ
neopeptide
POLE
ultramutation
DNA polymerase ε
ultramutation
POLE
neopeptide
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Summary:Endometrial cancers (ECs) with POLE proofreading mutations are typified by ultramutation and excellent prognosis. We investigated whether these were related, and found that POLE-mutant ECs display a robust T cell response that corresponds to an enrichment of antigenic tumor neopeptides. Enhanced immunogenicity may explain the favorable outcome of POLE-mutant ECs.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:2162-4011
2162-402X
2162-402X
DOI:10.1080/2162402X.2015.1072675