5-HT1A receptor blockade targeting the basolateral amygdala improved stress-induced impairment of memory consolidation and retrieval in rats

• Published in: Neuroscience Vol. 300; pp. 609 - 618
• Main Authors: Sardari, M, Rezayof, A, Zarrindast, M.-R
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 06.08.2015
• Subjects: (S)-WAY-100135; Acute Disease; acute elevated platform stress; Animals; basolateral amygdala; Basolateral Nuclear Complex - drug effects; Basolateral Nuclear Complex - physiopathology; Catheters, Indwelling; Disease Models, Animal; Male; Memory Consolidation - drug effects; Memory Consolidation - physiology; Memory Disorders - drug therapy; Memory Disorders - physiopathology; memory formation; Memory, Long-Term - drug effects; Memory, Long-Term - physiology; Mental Recall - drug effects; Mental Recall - physiology; Neurology; Nootropic Agents - pharmacology; Piperazines - pharmacology; rat(s); Rats, Wistar; Receptor, Serotonin, 5-HT1A - metabolism; Serotonin 5-HT1 Receptor Antagonists - pharmacology; Stress, Psychological - drug therapy; Stress, Psychological - physiopathology; DRN; LTP; EP; rat(s); corticotropin-releasing factor; dorsal raphe nucleus; serotonin; analysis of variance; ANOVA; memory formation; BLA; CRF; (S)-WAY-100135; HPA; hypothalamo–pituitary–adrenal; basolateral amygdala; 5-HT; elevated platform; (S)-N-tert-butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide; long-term potentiation; acute elevated platform stress
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2015.05.031

Highlights • Post-training or pre-test exposure to acute stress-induced memory impairment. • Re-exposure to acute stress-induced state-dependent memory retrieval. • Post-training BLA-targeted injection of (S)-WAY-100135 inhibited stress-induced impairment of memory consolidation. • Pre-test BLA-targeted injection of (S)-WAY-100135 inhibited stress-induced impairment of memory retrieval. • Blockade of 5-HT-1A receptors inhibited the stress-induced state-dependent memory retrieval.