Abnormal functional connectivity of the frontostriatal circuits in type 2 diabetes mellitus

• Published in: Frontiers in aging neuroscience Vol. 14; p. 1055172
• Main Authors: Fu, Yingxia, Gu, Meiling, Wang, Rui, Xu, Juan, Sun, Shenglu, Zhang, Huifeng, Huang, Dejian, Zhang, Zongjun, Peng, Fei, Lin, Pan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 04.01.2023
• Subjects: Aging Neuroscience; frontostriatal circuits; functional connectivity; functional magnetic resonance imaging; resting-state; type 2 diabetes mellitus; type 2 diabetes mellitus; functional connectivity; functional magnetic resonance imaging; resting-state; frontostriatal circuits
• ISSN: 1663-4365; 1663-4365
• DOI: 10.3389/fnagi.2022.1055172

Type 2 diabetes mellitus (T2DM) is a metabolic disorder associated with an increased incidence of cognitive and emotional disorders. Previous studies have indicated that the frontostriatal circuits play a significant role in brain disorders. However, few studies have investigated functional connectivity (FC) abnormalities in the frontostriatal circuits in T2DM. We aimed to investigate the abnormal functional connectivity (FC) of the frontostriatal circuits in patients with T2DM and to explore the relationship between abnormal FC and diabetes-related variables. Twenty-seven patients with T2DM were selected as the patient group, and 27 healthy peoples were selected as the healthy controls (HCs). The two groups were matched for age and sex. In addition, all subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological evaluation. Seed-based FC analyses were performed by placing six bilateral pairs of seeds within defined subdivisions of the striatum. The functional connection strength of subdivisions of the striatum was compared between the two groups and correlated with each clinical variable. Patients with T2DM showed abnormalities in the FC of the frontostriatal circuits. Our findings show significantly reduced FC between the right caudate nucleus and left precentral gyrus (LPCG) in the patients with T2DM compared to the HCs. The FC between the prefrontal cortex (left inferior frontal gyrus, left frontal pole, right frontal pole, and right middle frontal gyrus) and the right caudate nucleus has a significant positive correlation with fasting blood glucose (FBG). The results showed abnormal FC of the frontostriatal circuits in T2DM patients, which might provide a new direction to investigate the neuropathological mechanisms of T2DM.