The recombinant C-terminal fragment of tetanus toxin protects against cholinotoxicity by intraseptal injection of β-amyloid peptide (25–35) in rats

• Published in: Neuroscience Vol. 315; pp. 18 - 30
• Main Authors: Patricio-Martínez, A, Mendieta, L, Martínez, I, Aguilera, J, Limón, I.D
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 19.02.2016
• Subjects: acetylcholinesterase; Acetylcholinesterase - metabolism; Amyloid beta-Peptides - toxicity; amyloid-β(25–35); Animals; Caspase 3 - metabolism; choline acetyltransferase; Choline O-Acetyltransferase - metabolism; Hc-TeTx; Hippocampus - drug effects; Hippocampus - metabolism; Hippocampus - pathology; Immunohistochemistry; Male; Maze Learning - drug effects; Maze Learning - physiology; medial septum; Neurology; Neuroprotective Agents - pharmacology; Nootropic Agents - pharmacology; Peptide Fragments - pharmacology; Peptide Fragments - toxicity; Random Allocation; Rats, Wistar; Septum of Brain - drug effects; Septum of Brain - metabolism; Septum of Brain - pathology; spatial memory; Spatial Memory - drug effects; Spatial Memory - physiology; Tetanus Toxin - pharmacology; reference errors; ACh; vesicular acetylcholine transporter; amino-cupric-silver; CNS; phosphate-buffered saline; medial septum; Aβ; amyloid-β (25–35); nerve growth factor; WM; tropomyosin receptor kinases; ChAT; PBS; AChE; Trks; AD; Hematoxylin and eosin; Alzheimer’s disease; C-terminal domain of tetanus toxin; H&E; MS; spatial memory; SSI; acetylcholinesterase; NGF; isotonic saline solution; working memory errors; β amyloid peptide; central nervous system; A-Cu-Ag; choline acetyltransferase; Hc-TeTx; acetylcholine; RM; VAChT; amyloid-β(25–35); amyloid-β((25–35))
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2015.11.066

Graphical abstract