Activation of cyclin D1-related kinase in human lung adenocarcinoma

• Published in: British Journal of Cancer Vol. 81; no. 4; pp. 705 - 711
• Main Authors: IGARASHI, K, MASAKI, T, OMATA, M, SHIRATORI, Y, RENGIFO, W, NAGATA, T, HARA, K, OKA, T, NAKAJIMA, J, HISADA, T, HATA, E
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Basingstoke Nature Publishing Group 01.10.1999
• Subjects: Adenocarcinoma - enzymology; Adenocarcinoma - pathology; Adult; Aged; Biological and medical sciences; Blotting, Western; Cyclin D1 - analysis; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinases - metabolism; Enzyme Activation; Female; Humans; Immunoblotting; Immunohistochemistry; Lung Neoplasms - enzymology; Lung Neoplasms - pathology; Male; Medical sciences; Middle Aged; Pneumology; Protein-Serine-Threonine Kinases - metabolism; Proto-Oncogene Proteins; Regular; Retinoblastoma Protein - analysis; Tumors of the respiratory system and mediastinum; Adenocarcinoma; Human; Lung disease; Respiratory disease; Malignant tumor; Cyclin D1; Carcinogenesis; Bronchopulmonary; Enzymatic activity; C-Onc gene; Malignant transformation; Bronchus disease; Genetics; Cyclin dependent kinase; Protooncogene; Non small cell carcinoma
• ISSN: 0007-0920; 1476-5381; 1532-1827
• DOI: 10.1038/sj.bjc.6690752

Cyclin D1 gene amplification is an important event in many cancers, but it is rarely found in non-small-cell lung cancer (NSCLC). This study was conducted in an attempt to clarify any other mechanisms related to cyclin D1 involvement in the malignant transformation of NSCLC, and we clearly showed for the first time that cyclin D1-related kinases are activated in NSCLC, especially in adenocarcinoma but not in squamous cell carcinoma. The results of this study strongly suggest that enhanced cyclin D1-related kinase activity could contribute to a progression of adenocarcinoma in NSCLC.