Anxiety provokes balance deficits that are selectively dopa-responsive in parkinson’s disease

Highlights • Anxiety influences balance control in PD, especially those who are highly anxious. • Dopamine appears to modulate anxiety, although it had limited effects on balance. • Anxiety did not habituate with continued exposure to threat in highly anxious PD.

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Bibliographic Details
Published in	Neuroscience Vol. 340; pp. 436 - 444
Main Authors	Ehgoetz Martens, Kaylena A, Lefaivre, Shannon C, Beck, Eric N, Chow, Rebecca, Pieruccini-Faria, Frederico, Ellard, Colin G, Almeida, Quincy J
Format	Journal Article
Language	English
Published	United States Elsevier Ltd 06.01.2017
Subjects	Aged Antiparkinson Agents - therapeutic use anxiety Anxiety - drug therapy Anxiety - physiopathology balance Dihydroxyphenylalanine - therapeutic use dopaminergic replacement therapy Female Humans Male Neurology Parkinson Disease - drug therapy Parkinson Disease - physiopathology Parkinson Disease - psychology Parkinson’s disease Postural Balance - drug effects Postural Balance - physiology postural stability Psychiatric Status Rating Scales Self Report Severity of Illness Index threat Dopaminergic replacement therapy Anxiety Balance Postural stability Parkinson’s disease Threat COP postural stability dopaminergic replacement therapy MLL AP STAI anxiety PD balance COG threat VR HMD
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Summary:	Highlights • Anxiety influences balance control in PD, especially those who are highly anxious. • Dopamine appears to modulate anxiety, although it had limited effects on balance. • Anxiety did not habituate with continued exposure to threat in highly anxious PD.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.11.011