The evolving biology of Mycobacterium tuberculosis drug resistance

Tuberculosis, caused by (Mtb) is an ancient disease that has remained a leading cause of infectious death. Mtb has evolved drug resistance to every antibiotic regimen ever introduced, greatly complicating treatment, lowering rates of cure and menacing TB control in parts of the world. As technology...

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Published inFrontiers in cellular and infection microbiology Vol. 12; p. 1027394
Main Authors Jones, Richard M, Adams, Kristin N, Eldesouky, Hassan E, Sherman, David R
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 05.10.2022
Subjects
antibiotics
Antitubercular Agents - pharmacology
Antitubercular Agents - therapeutic use
Biology
Cellular and Infection Microbiology
Drug Resistance
heterogeneity
Humans
mycobacteria
Mycobacterium tuberculosis - genetics
resistance
tolerance
tuberculosis
Tuberculosis, Lymph Node
antibiotics
mycobacteria
heterogeneity
resistance
tolerance
tuberculosis
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Summary:Tuberculosis, caused by (Mtb) is an ancient disease that has remained a leading cause of infectious death. Mtb has evolved drug resistance to every antibiotic regimen ever introduced, greatly complicating treatment, lowering rates of cure and menacing TB control in parts of the world. As technology has advanced, our understanding of antimicrobial resistance has improved, and our models of the phenomenon have evolved. In this review, we focus on recent research progress that supports an updated model for the evolution of drug resistance in Mtb. We highlight the contribution of drug tolerance on the path to resistance, and the influence of heterogeneity on tolerance. Resistance is likely to remain an issue for as long as drugs are needed to treat TB. However, with technology driving new insights and careful management of newly developed resources, antimicrobial resistance need not continue to threaten global progress against TB, as it has done for decades.
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This article was submitted to Molecular Bacterial Pathogenesis, a section of the journal Frontiers in Cellular and Infection Microbiology
Reviewed by: Thomas Dick, Hackensack Meridian Health, United States; Anna D. Tischler, University of Minnesota Twin Cities, United States; Alexandre Gouzy, NewYork-Presbyterian, United States
Edited by: Ben Gold, Weill Cornell Medicine, United States
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2022.1027394