Biomarkers of autoimmunity and beta cell metabolism in type 1 diabetes

• Published in: Frontiers in immunology Vol. 13; p. 1028130
• Main Authors: Yang, Mei-Ling, Kibbey, Richard G., Mamula, Mark J.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 27.10.2022
• Subjects: Autoimmune Diseases - metabolism; Autoimmunity; biomarkers; Biomarkers - metabolism; Diabetes Mellitus, Type 1; glucose metabolism; Humans; Immunology; Insulin-Secreting Cells; neoepitopes; posttranslational modifications; type 1 diabetes; type 1 diabetes; neoepitopes; posttranslational modifications; glucose metabolism; biomarkers

Posttranslational protein modifications (PTMs) are an inherent response to physiological changes causing altered protein structure and potentially modulating important biological functions of the modified protein. Besides cellular metabolic pathways that may be dictated by PTMs, the subtle change of...