Effect of botulinum toxin type A on non-motor symptoms and quality of life in Meige syndrome

• Published in: Frontiers in neurology Vol. 14; p. 1115482
• Main Authors: Zheng, Heqing, Wu, Lanxiang, Tian, Sheng, Liu, Mingxu, Zhan, Qingqing, Yu, Xinping, Xie, Yonggang, Zhong, Xianhui, Wu, Wei
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 09.02.2023
• Subjects: botulinum toxin; Meige syndrome; Neurology; non-motor symptoms; psychiatric disturbances; quality of life; botulinum toxin; psychiatric disturbances; quality of life; non-motor symptoms; Meige syndrome
• ISSN: 1664-2295; 1664-2295
• DOI: 10.3389/fneur.2023.1115482

It has been shown in previous studies that botulinum toxin type A (BTX-A) can effectively relieve the motor symptoms of Meige syndrome. However, its effect on non-motor symptoms (NMS) and quality of life (QoL) has not been comprehensively studied. This study aimed to explore the effects of BTX-A on NMS and QoL and to clarify the relationship between changes in motor symptoms, NMS, and QoL after BTX-A. Seventy-five patients were recruited for the study. All patients were assessed by a series of clinical assessments before, one, and 3 months after BTX-A treatment. Dystonic symptoms, psychiatric disturbances, sleep disorders, and QoL were evaluated. After 1 and 3 months of BTX-A treatment, the scores of motor symptoms, anxiety, and depression were significantly decreased ( < 0.05). Except for general health, the scores of the other 36-item short-form health survey QoL subitems were significantly improved after BTX-A ( < 0.05). After 1 month of treatment, the changes in anxiety and depression were not correlated with changes in motor symptoms ( > 0.05). Still, they were negatively correlated with changes in physical functioning, role-physical and mental component summary QoL ( < 0.05). BTX-A effectively improved motor symptoms, anxiety, depression, and QoL. Anxiety and depression improvement did not correlate with motor symptom changes after BTX-A, and QoL improvements were strongly associated with psychiatric disturbances.