Alteration of major vault protein in human glioblastoma and its relation with EGFR and PTEN status

• Published in: Neuroscience Vol. 297; pp. 243 - 251
• Main Authors: Navarro, L, Gil-Benso, R, Megías, J, Muñoz-Hidalgo, L, San-Miguel, T, Callaghan, R.C, González-Darder, J.M, López-Ginés, C, Cerdá-Nicolás, M.J
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 25.06.2015
• Subjects: Adult; Aged; Brain Neoplasms - genetics; Brain Neoplasms - metabolism; Chromosomes, Human, Pair 7 - genetics; epidermal growth factor receptor variant III (EGFRvIII); epidermal growth factor receptor wild type (EGFRwt); Female; Gene Expression Regulation, Neoplastic - genetics; glioblastoma (GBM); Glioblastoma - genetics; Glioblastoma - metabolism; Humans; major vault protein (MVP); Male; Middle Aged; multiplex ligation-dependent probe amplification (MLPA); Mutation - genetics; Neurology; phosphatase and tensin homolog (PTEN); PTEN Phosphohydrolase - genetics; PTEN Phosphohydrolase - metabolism; Receptor, Epidermal Growth Factor - genetics; Receptor, Epidermal Growth Factor - metabolism; Statistics, Nonparametric; Vault Ribonucleoprotein Particles - metabolism; Young Adult; fluorescent in situ hybridization; epidermal growth factor receptor wild type (EGFRwt); PTEN; epidermal growth factor receptor variant III (EGFRvIII); EGFR variant III mutation; EGFR; KPS; MPV; GBM; HPFs; EGFRvIII; epidermal growth factor receptor; major vault protein; high-power fields; phosphatase and tensin homolog (PTEN); phosphatase and tensin homolog; GFAP; multiplex ligation-dependent probe amplification; glioblastoma; MLPA; FISH; glioblastoma (GBM); multiplex ligation-dependent probe amplification (MLPA); major vault protein (MVP); Karnofsky performance status; glial fibrillary acidic protein
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2015.04.005

Highlights • We examined EGFR, PTEN and MVP gene dosages in 113 samples from GBM. • A significant inverse correlation between MVP and PTEN gene copies was determined. • Lower MVP gene dosages correlated with higher survival of patients with chemotherapy. • MVP may be a novel and interesting target for new treatments in GBM.